Prevalence, aetiology and antimicrobial resistance profile of diabetic individuals suffering from community-acquired urinary tract infection.

The rise in antimicrobial resistance poses a significant threat to global health, particularly among diabetic patients who are prone to urinary tract infections (UTIs). Pathogens that cause UTI among diabetic patients exhibit significant multidrug resistance (MDR) patterns, necessitating more precise empirical treatment strategies..

Advancements in framework materials for enhanced energy harvesting.

Energy harvesting, the process of capturing ambient energy from various sources and converting it into usable electrical power, has attracted a lot of attention due to its potential to provide long-term and self-sufficient energy solutions. This comprehensive review thoroughly explores the use of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) for energy harvesting by piezoelectric and triboelectric nanogenerators (PENGs and TENGs). It begins by classifying and outlining the structural diversity of MOFs and COFs, which is key to understanding their importance in energy applications.

Exploring Platelet Indices as Predictors of Nephropathy Severity in Type 2 Diabetes Mellitus: A Hospital-Based Cross-Sectional Analysis.

Background Increased platelet activity in type 2 diabetes mellitus (T2DM) plays a key role in the development of vascular complications. Platelet indices such as mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (PLCR), and plateletcrit (PCT) reflect both the functional and morphological status of platelets. These indices are markers of inflammation and metabolic dysregulation, which are pivotal in diabetic vasculopathy.

Efficacy of Nebulized Dexmedetomidine and Lignocaine Inhalation versus Lignocaine Alone as Premedication for Flexible Fiber-optic Bronchoscopy under Sedation: A Randomized Comparative Study.

Introduction: Airway management is an integral part of general anesthesia, allowing ventilation and oxygenation and working as a mode for delivering anesthetic gases. Awake fiber-optic-guided intubation is an essential component of airway management in difficult cases. We aim to study the benefits of nebulized dexmedetomidine with lignocaine over lignocaine alone for anesthetizing the airway for flexible fiber-optic bronchoscopy.

Clinically Suspicious Cases of Hansen's Disease at a Tertiary Care Hospital in South India: A Clinicopathological Study.

Background and objective Hansen's disease, also known as leprosy, is a chronic granulomatous condition caused by , primarily affecting the skin and peripheral nerves. The disease has a wide spectrum of clinical and histopathological manifestations, often mimicking other inflammatory and infectious conditions. This variability poses significant challenges in its early diagnosis and management.

Geospatial analysis of food waste generation at the consumer-level in high-income regions, 2000-2023 - A scoping review.

Food waste (FW) is a growing problem globally, with around 13% of food lost from harvest to retail, and another 17% wasted by retailers, households, and the food service sector. In high-income countries, consumer-level FW, primarily originates from private households and the food service sector, forming the largest waste stream in the food supply chain. Despite extensive research on FW, there is still a lack of knowledge about its geographic distribution, sources, spatial locations, and volume, impeding effective waste management strategies.

Early adoption of innovation in HPV prevention strategies: closing the gap in cervical cancer.

Cervical cancer (CC) is one of the highest prevailing causes of female cancer-related mortality globally. A significant discrepancy in incidence has been noted between high and low-middle-income countries. The origins of CC have been accredited to the human papillomavirus (HPV) with serotypes 16 and 18 being the most prevalent.

Understanding the motional dynamics of the ammonium ion in the mechanism of multiferroicity of Cr(V) peroxychromates: a H NMR study.

Cr(5+)-based peroxychromates, MCr(O), with M = NH or a mixed NH-alkali metal are a new class of multiferroics for potential use in molecular memory devices, with the NH being a key element, but the underlying chemical mechanism is not fully understood. The NH ion occupies two different sites, but their specific roles are not known. We thus performed detailed H NMR spin-relaxation () measurements on (NH)Cr(O) over a wide temperature range (120-300 K) to probe the displacive as well as hindered rotational dynamics of the NH ions with the view of understanding their specific roles in the phase transitions.

Cost of treating rheumatoid arthritis in the primary care public health system in Ireland: A time-driven activity-based cost analysis.

Background: Chronic diseases are at epidemic proportions and continuing to increase in both incidence and prevalence globally. Therefore, there is a growing need to assess and improve on the value currently provided within chronic care pathways. Examining the costs associated with care pathways is a critical part of assessing this value in order to better understand and introduce potential cost-saving interventions.

Enhancing soil quality and yield through microbial assisted in-situ residue management in rice-rice cropping system in Odisha, Eastern India.

Crop residue management has become more challenging with intensive agricultural operations. Zero tillage and crop residue returns, along with the enhancement of in-situ residue decomposition through microbial intervention, are essential measures for preserving and enhancing soil quality. To address this problem in view of stubble burning, field experiments were conducted in rice-rice (variety Swarna) cropping systems under lowland conditions, wherein the following different residue management practices were adopted viz.

Elucidating the anti-cancer potential of essential oil against non-small cell lung cancer: A multifaceted approach involving GC-MS profiling, network pharmacology, and molecular dynamics simulations.

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Strigolactone GR24-mediated mitigation of phosphorus deficiency through mycorrhization in aerobic rice.

Strigolactones (SLs) are a new class of plant hormones that play a significant role in regulating various aspects of plant growth promotion, stress tolerance and influence the rhizospheric microbiome. GR24 is a synthetic SL analog used in scientific research to understand the effects of SL on plants and to act as a plant growth promoter. This study aimed to conduct hormonal seed priming at different concentrations of GR24 (0.

Dynamic life cycle assessment of commercial and household food waste: A critical global review of emerging techniques.

DLCA has been applied to several food waste streams, however, to date no critical assessment of its strengths, weaknesses, opportunities, and threats (SWOT) is available in the scientific literature. Accordingly, the present review aims to provide a comprehensive overview of the available literature on DLCA and its application to Household and Commercial Food Waste (HCFW) by providing critical assessment and perspectives for future research. The Population, Intervention, Comparison, and Outcome (PICO) framework for literature review was employed, with just 12 relevant studies identified between 1999 and 2022, highlighting a dearth of research on DLCA of food waste and the need for further research.

Exploration of Antileishmanial Compounds Derived from Natural Sources.

Aims: Leishmaniasis is a deadly tropical disease that is neglected in many countries. World Health Organization, along with a few other countries, has been working together to protect against these parasites. Many novel drugs from the past few years have been discovered and subjected against leishmaniasis, which have been effective but they are quite expensive for lower-class people.

Genetics and epigenetics of diabetes and its complications in India.

Diabetes mellitus (DM) has become a significant health concern with an increasing rate of morbidity and mortality worldwide. India ranks second in the number of diabetes cases in the world. The increasing burden of DM can be explained by genetic predisposition of Indians to type 2 diabetes mellitus (T2DM) coupled with rapid urbanization and socio-economic development in the last 3 decades leading to drastic changes in lifestyle.

Reduced Endothelial Progenitor Cells: A Possible Biomarker for Idiopathic Fetal Growth Restriction in Human Pregnancies.

Background: Circulating endothelial progenitor cells (EPCs) may be necessary throughout pregnancy by ensuring proper placentation and embryonic growth. The lack of standardized EPC quantification techniques has prevented conclusive proof of an increase in EPC during pregnancy.

Objectives: The purpose of this study was to determine whether EPC levels change for healthy and idiopathic fetal growth restriction (FGR) pregnancies.

Linking of oxidative stress and mitochondrial DNA damage to the pathophysiology of idiopathic intrauterine growth restriction.

Objective: A common and serious pregnancy issue known as intrauterine growth restriction (IUGR) occurs when the fetus is unable to reach its full growth potential. Mitochondria are crucial to the development of the fetus and the placenta. We aimed to elucidate the role of oxidative stress parameters and markers of DNA damage.

Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases.

The progression of proteinuric kidney diseases is associated with podocyte loss, but the mechanisms underlying this process remain unclear. Podocytes reenter the cell cycle to repair double-stranded DNA breaks. However, unsuccessful repair can result in podocytes crossing the G1/S checkpoint and undergoing abortive cytokinesis.

Identifying Novel Data-Driven Dietary Patterns via Dimensionality Reduction and Associations with Socioeconomic Profile and Health Outcomes in Ireland.

Dietary patterns and body mass index (BMI) play a significant role in the development of noncommunicable diseases (NCDs), which are the leading cause of mortality worldwide, including Ireland. A cross-sectional survey was conducted across Ireland to collate respondents' socioeconomic profiles, health status, and dietary patterns with a representative sample size of 957 adult respondents. Principal component analysis (PCA) and statistical analyses were subsequently employed.

Therapeutic applications of nanobiotechnology.

Nanobiotechnology, as a novel and more specialized branch of science, has provided a number of nanostructures such as nanoparticles, by utilizing the methods, techniques, and protocols of other branches of science. Due to the unique features and physiobiological characteristics, these nanostructures or nanocarriers have provided vast methods and therapeutic techniques, against microbial infections and cancers and for tissue regeneration, tissue engineering, and immunotherapies, and for gene therapies, through drug delivery systems. However, reduced carrying capacity, abrupt and non-targeted delivery, and solubility of therapeutic agents, can affect the therapeutic applications of these biotechnological products.

Biodegradation of Phenol Using the Indigenous Rhodococcus pyridinivorans Strain PDB9T NS-1 Immobilized in Calcium Alginate Beads.

Phenolic compounds are the major contaminants identified from various industrial effluents, which pose an extreme threat to the environment. Therefore, investigating an effective technique to remove these toxic phenolic compounds from the contaminated environment is very essential. In the present investigation, batch tests were performed to assess the biodegradation of phenol using an indigenous Rhodococcus pyridinivorans strain PDB9T NS-1 encapsulated in a calcium alginate bead system.

"Mind the Gap" - An overview of the role of the Extensions Community Healthcare Outcomes (ECHO) model in enhancing value in health care delivery.

The ECHO (Extensions Community Healthcare Outcomes) model of healthcare delivery has grown rapidly since its establishment and increased in popularity in recent years. This expansion has developed alongside the growing incidence of chronic diseases and the need to better manage them. The increasing uptake in ECHO has presented a requirement to assess its true value as healthcare costs are increasing globally, resulting in a growing demand by governments and policy makers to ensure chronic disease management strategies provide true value.