Metal implant allergy: A retrospective cohort analysis at a university allergy practice.

Concern of metal sensitization in pre- and postsurgical evaluation is growing, with the recent guidelines remaining the criterion standard for consideration of patch testing. Information remains scarce on surgical screening in the groups of patients who reported a history of metal sensitivity versus those with no reported history. The objective of this study was to assess the utility of patch testing in surgical candidates based on reported metal allergy history.

Voice Pathologies and the General Population's Perception.

Objectives: To examine how the general population perceives voice pathology based on subjective qualities.

Study Design: Descriptive, cross-sectional, survey-based study.

Methods: This is an IRB-approved Qualtrics survey on Amazon MTurk for respondents ages 18 and older.

Myringotomy tube placement: understanding the impact of the coronavirus disease 2019 pandemic.

Objective: Otolaryngologists perform bilateral myringotomy and tube placement for surgical management for otitis media with effusion. This retrospective study aimed to address the extent to which the coronavirus disease 2019 pandemic and season impact the number of bilateral myringotomy and tube placement procedures performed at a tertiary care centre.

Methods: A total of 1248 charts of children who underwent bilateral myringotomy and tube placement from January 2018 through February 2021 were reviewed.

Predictors of voice therapy efficacy in vocal cord dysfunction at a tertiary care center.

Objective: Vocal cord dysfunction is inappropriate adduction of vocal cords during inspiration that causes dyspnea and is commonly mistaken for exercise-induced asthma. To improve diagnostic accuracy, this study aims to identify demographics associated with vocal cord dysfunction and to determine their impact on the efficacy of voice therapy in improving vocal cord function.

Study Design: Retrospective chart review.

Race and Gender in Ophthalmology: A National Analysis of Medical Students with Intention to Pursue the Field.

 The field of ophthalmology must become more reflective of the increasingly diverse U.S. population.

Assessment of the Wisconsin Criteria at a Level I Trauma Center.

The Wisconsin Criteria was developed for physicians evaluating facial trauma to determine the likelihood of facial fractures. Subsequent studies have not consistently validated these criteria. This study seeks to validate the Wisconsin Criteria and determine its utility in predicting operative facial fractures.

Otolaryngology Department and Society Leadership: Evaluation of Diversity in a Nationwide Study.

Objectives/hypothesis: Diversity in medicine positively influences healthcare delivery. As we aim to make otolaryngology more diverse, it is essential to analyze our current leadership.

Study Design: Observational study.

Diversity in Academic Laryngology: An Evaluation of Academic Advancement and Research Productivity.

Background: Diversity within the medical profession with respect to sex and racial minorities has been shown to have a positive effect on health and healthcare. Characterization of a field is key to evaluating trends and the advancement of diversity in an otolaryngology subspecialty.

Study Design: Observational study.

Pterocarpus marsupium extract extends replicative lifespan in budding yeast.

As the molecular mechanisms of biological aging become better understood, there is growing interest in identifying interventions that target those mechanisms to promote extended health and longevity. The budding yeast Saccharomyces cerevisiae has served as a premier model organism for identifying genetic and molecular factors that modulate cellular aging and is a powerful system in which to evaluate candidate longevity interventions. Here we screened a collection of natural products and natural product mixtures for effects on the growth rate, mTOR-mediated growth inhibition, and replicative lifespan.

Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes.

Mutations accumulate within somatic cells and have been proposed to contribute to aging. It is unclear what level of mutation burden may be required to consistently reduce cellular lifespan. Human cancers driven by a mutator phenotype represent an intriguing model to test this hypothesis, since they carry the highest mutation burdens of any human cell.

Safety and efficacy of metformin for therapy-induced hyperglycemia in children with acute lymphoblastic leukemia.

Background: Hyperglycemia during corticosteroid and asparaginase therapy for acute lymphoblastic leukemia is a significant side effect that is usually treated with insulin. Metformin is an oral antidiabetic biguanide that may cause metabolic acidosis and liver enzyme abnormalities of possible concern in patients receiving chemotherapy.

Procedure: We reviewed patients with acute lymphoblastic leukemia treated with corticosteroids and asparaginase who received metformin for control of hyperglycemia.