A new pyranopyrazole based colorimetric chemosensor for the selective recognition of biothiols: applications in real samples.

Here, we present the development of a pyranopyrazole-based chemosensor (P1) that serves as a reliable colorimetric chemosensor for the identification of biothiols, namely glutathione (GSH), homocysteine (Hcy), and cysteine (Cys). We extensively studied the interaction of P1 with several amino acids (Cys, Ala, His, Ile, Leu, Lys, Ser, Trp, Val, Pro, Phe, Arg) and other biothiols (Hcy and GSH) using colorimetric methods and UV-visible spectroscopy. The results indicated that P1 endures a visible color change in the presence of biothiols, rendering it a practical tool for detection.

Synthesis and bio-evaluation of newer dihydropyridines and tetrahydropyridines based glycomimetic azasugars.

This study presents the synthesis and bio-evaluation of new triazolylated dihydropyridine and tetrahydropyridine azasugar scaffolds (F1-14). Azasugar glycomimetics are the synthetic substances that mimic the structural and functional characteristics of natural carbohydrates showcasing promising potential as therapeutic agents for diabetes. The α-glucosidase inhibitory activity of synthesized final compounds were evaluated against the commercially available α-glucosidase enzyme.

Design, synthesis and evaluation of newer 1,4-dihydropyridine based amlodipine bio-isosteres as promising antihypertensive agents.

Hypertension remains a major global health concern, prompting ongoing research into innovative therapeutic approaches. This research encompasses the strategic design, synthesis, and computational assessment of a novel series of 1,4-dihydropyridine based scaffolds with the objective of developing promising antihypertensive agents as viable alternatives to the well-established dihydropyridine based drugs such as amlodipine, felodipine, nicardipine, The crystal structure of the lead compound determined using X-ray crystallography offers crucial insights into its 3D-conformation and intermolecular interactions. molecular docking experiments conducted against the calcium channel responsible for blood pressure regulation revealed superior docking scores for all the bioisosteres P1-P14 than the standard amlodipine, indicating their potential for enhanced therapeutic efficacy.