Inhibition of tissue factor pathway inhibitor by the aptamer BAX499 improves clotting of hemophilic blood and plasma.

Background: Tissue factor pathway inhibitor (TFPI) is the major inhibitor of tissue factor-initiated coagulation, making it an interesting and novel therapeutic target in hemophilia treatment. The aptamer BAX499 (formerly ARC19499) is designed to improve hemostasis by specifically inhibiting TFPI.

Objectives: The aim of the study was to examine the concentration-dependent augmentation of clotting by BAX499.

Resorcinol ninhydrin complex: 1,5,9-trihy-droxy-8-oxatetra-cyclo-[7.7.0.0(2,7).0(10,15)]hexa-deca-2,4,6,10(15),11,13-hexaen-16-one.

In the title compound, C(15)H(10)O(5), the cyclo-penta-none (r.m.s.

Cut margins and disease control in oral cancers.

Aim: This retrospective study was done to evaluate the impact of cut margins on disease-free survival in patients with previously untreated oral squamous cell cancers.

Materials And Methods: Records of 306 cases were reviewed for clinical details and status of margins at resection. The independent influence of margins on recurrence was analyzed.

Nanostructured lead-free ferroelectric Na0.5Bi0.5TiO3-BaTiO3 whiskers: synthesis mechanism and structure.

Nanostructured lead-free ferroelectric Na(0.5)Bi(0.5)TiO(3)-BaTiO(3) (NBTBT) whiskers with a high aspect ratio were synthesized topochemically using Na(2)Ti(6)O(13) (NTO) as a host structure for the first time.

1-[5-(4-Chloro-phen-yl)-3-(4-hy-droxy-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]-ethanone.

In the title compound, C(17)H(15)ClN(2)O(2), the benzene rings form dihedral angles of 89.56 (5) and 5.87 (5)° with the mean plane of the pyrazoline ring (r.

Naked eye detection of nitric oxide release from nitrosothiols aided by gold nanoparticles.

In this work we have demonstrated that nitric oxide can be monitored spectrophotometrically using cyclodextrin encapsulated ferrocene. The detection course showed the colour change from yellow to blue which can be detected with the naked eye. Also we describe the catalytic effect of gold nanoparticles in enhancing nitric oxide release from S-nitrosothiols.

L-shaped piezoelectric motor--part II: analytical modeling.

This paper develops an analytical model for an L-shaped piezoelectric motor. The motor structure has been described in detail in Part I of this study. The coupling of the bending vibration mode of the bimorphs results in an elliptical motion at the tip.

L-shaped piezoelectric motor--part I: design and experimental analysis.

This paper proposes an L-shaped piezoelectric motor consisting of two piezoelectric bimorphs of different lengths arranged perpendicularly to each other. The coupling of the bending vibration mode of the bimorphs results in an elliptical motion at the tip. A detailed finite element model was developed to optimize the dimensions of bimorph to achieve an effective coupling at the resonance frequency of 246 Hz.

Heavy metal assessment using geochemical and statistical tools in the surface sediments of Vembanad Lake, Southwest Coast of India.

The geochemical distribution and enrichment of ten heavy metals in the surface sediments of Vembanad Lake, southwest coast of India was evaluated. Sediment samples from 47 stations in the Lake were collected during dry and wet seasons in 2008 and examined for heavy metal content (Al, Fe, Mn, Cr, Zn, Ni, Pb, Cu, Co, Cd), organic carbon, and sediment texture. Statistically significant spatial variation was observed among all sediment variables, but negligible significant seasonal variation was observed.

Autoimmune thyroid disease in patients with vitiligo: prevalence study in India.

Objective: To identify the prevalence of autoimmune thyroid disease (AITD) in Asian Indian patients with vitiligo and to compare the clinical profile between thyroid peroxidase (TPO) antibody-positive and TPO antibody-negative groups.

Methods: In this cross-sectional, case-controlled study, 50 patients with vitiligo (29 women and 21 men) were included. Patients with previous disorders, irradiation, or surgical procedures involving the thyroid were excluded from the study.

Diabetes in young--unusual case presentation.

Diabetes in young is increasing in prevalence with each decade. Phenotypic features like obesity and acanthosis nigricans characterize type 2 diabetes, whereas autoimmune diseases like vitiligo and hypothyroidism suggest type 1 diabetes. We recently encountered a young boy with vitiligo who presented with hyperglycemia, but not associated with ketonuria and has underlying chronic pancreatitis with secondary diabetes.

Morphology to morphometry in cytological evaluation of thyroid lesions.

Aim: To evaluate the cytomorphometric features in fine needle aspiration cytology (FNAC) of thyroid lesions.

Materials And Methods: FNAC of 36 thyroid cases was reviewed. The study included 10 cases each of follicular lesion, adenomatous goiter, papillary carcinoma, 4 cases of medullary carcinoma and 2 cases of anaplastic carcinoma.

Fecal contamination of drinking water supplies in and around Chandigarh and correlation with acute gastroenteritis.

The study evaluated drinking water from localities in and around Chandigarh for fecal coliforms, V. cholerae and Enterotoxigenic E. coli and correlate with occurrence of acute gastroenteritis occurring from the same region.

A biomimetic robotic jellyfish (Robojelly) actuated by shape memory alloy composite actuators.

An analysis is conducted on the design, fabrication and performance of an underwater vehicle mimicking the propulsion mechanism and physical appearance of a medusa (jellyfish). The robotic jellyfish called Robojelly mimics the morphology and kinematics of the Aurelia aurita species. Robojelly actuates using bio-inspired shape memory alloy composite actuators.

Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells.

Nimbolide, a plant-derived limonoid has been shown to exert its antiproliferative effects in various cell lines. We demonstrate that nimbolide effectively inhibited proliferation of WiDr colon cancer cells through inhibition of cyclin A leading to S phase arrest. It also caused activation of caspase-mediated apoptosis through the inhibition of ERK1/2 and activation of p38 and JNK1/2.

Influence of N-acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats.

This study evaluates the hepatoprotective and antioxidant properties of N-acetylcysteine (NAC) on dimethylnitrosamine (DMN) induced hepatotoxicity in male Wistar albino rats. A single intraperitoneal dose of DMN (5 mg/kg b.w.

Magnetic control of ferroelectric interfaces.

We report the strong magnetic field dependence of ferroelectric PbZr(0.52)Ti(0.48)O(3) (PZT) films on half-metallic oxide La(0.

Magnetoelectric Interactions in Lead-Based and Lead-Free Composites.

Magnetoelectric (ME) composites that simultaneously exhibit ferroelectricity and ferromagnetism have recently gained significant attention as evident by the increasing number of publications. These research activities are direct results of the fact that multiferroic magnetoelectrics offer significant technological promise for multiple devices. Appropriate choice of phases with co-firing capability, magnetostriction and piezoelectric coefficient, such as Ni-PZT and NZFO-PZT, has resulted in fabrication of prototype components that promise transition.

Preliminary radiological safety assessment for decommissioning of thoria dissolver of the ²³³U pilot plant, Trombay.

The thoria dissolver, used for separation of (233)U from reactor-irradiated thorium metal and thorium oxide rods, is no longer operational. It was decided to carry out assessment of the radiological status of the dissolver cell for planning of the future decommissioning/dismantling operations. The dissolver interiors are expected to be contaminated with the dissolution remains of irradiated thorium oxide rods in addition to some of the partially dissolved thoria pellets.

Criterion for material selection in design of bulk piezoelectric energy harvesters.

Vibration energy harvesting has gained tremendous attention in the past decade and continues to grow rapidly. There are various transduction mechanisms for converting the vibration energy into electrical energy, out of which the piezoelectric mechanism has been shown to provide advantages at the micro-to-meso scale. In the past few years, several studies have tried to address the question of which piezoelectric composition is better for energy harvesting; however, discussion on this subject continues.

Design and fabrication of bimorph transducer for optimal vibration energy harvesting.

High energy density piezoelectric composition corresponding to 0.9Pb(Zr0.56Ti0.

Protective effect of Livactine against CCl(4) and paracetamol induced hepatotoxicity in adult Wistar rats.

Background: Liver disease has become one of the serious health problems as it is exposed to many kinds of xenobiotics and therapeutic agents. Moreover the rapidly growing morbidity and mortality from liver disease are attributable to the increasing number of chemical compounds and environmental pollution. Unfortunately, so far, in the modern era of medicine there is no specific treatment to counter the menacing impact of these dreaded diseases.

Moringa oleifera prevents selenite-induced cataractogenesis in rat pups.

Purpose: The aim of this study was to investigate the protective effects of the flavonoid fraction of Moringa oleifera leaves (FMO) on selenite cataract in vivo.

Methods: Rat pups of Sprague-Dawley strain initially weighing 10–12 g on day 8 were used for the study and grouped as control (G I), selenite induced (G II), and FMO treated (G III). The rat pups in G II and G III received a single subcutaneous injection of sodium selenite (4 µg/g body weight) on day 10 and G III was administered with FMO (2.