Wide-field individual retinal layer thickness in healthy eyes.

Purpose: To report the individual retinal layer thickness in healthy subjects using wide-field optical coherence tomography.

Methods: This was a prospective, cross-sectional study involving healthy subjects. A custom-designed semiautomated segmentation algorithm was used to split the retinal layers in seven bands, and individual retinal layer thicknesses were measured in horizontal (nasal, macular, and temporal segments) and vertical meridians (superior, macular, and inferior segments).

Three-year outcomes from the CRADLE study in de novo pediatric kidney transplant recipients receiving everolimus with reduced tacrolimus and early steroid withdrawal.

CRADLE was a 36-month multicenter study in pediatric (≥1 to <18 years) kidney transplant recipients randomized at 4 to 6 weeks posttransplant to receive everolimus + reduced-exposure tacrolimus (EVR + rTAC; n = 52) with corticosteroid withdrawal at 6-month posttransplant or continue mycophenolate mofetil + standard-exposure TAC (MMF + sTAC; n = 54) with corticosteroids. The incidence of composite efficacy failure (biopsy-proven acute rejection [BPAR], graft loss, or death) at month 36 was 9.8% vs 9.

Comparison of Loading Doses of Ziv-Aflibercept and Aflibercept in Neovascular Age-Related Macular Degeneration.

Purpose: The aim of this study was to compare outcomes of 3 loading doses of ziv-aflibercept and aflibercept in treatment-naïve neovascular age-related macular degeneration (nAMD).

Design: Retrospective, nonrandomized, comparative study.

Methods: This was a retrospective chart review which included cases with treatment-naïve nAMD.

Telbivudine tenofovir in hepatitis B e antigen-negative chronic hepatitis B patients: OPTIMA roadmap study.

Aim: To make efficacy and safety comparison of telbivudine-raodmap and tenofovir-roadmap in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients.

Methods: This was the first prospective, randomised, two-arm, open-label, non-inferiority study in HBeAg-negative CHB patients that compared telbivudine and tenofovir administered as per roadmap concept. Patients were treated up to 24 wk and, depending on virologic response, continued the same therapy or received add-on therapy up to 104 wk.

Anal anatomy and normal histology.

The focus of this article is the anatomy and histology of the anal canal, and its clinical relevance to anal cancers. The article also highlights the recent histological and anatomical changes to the traditional terminology of the anal canal. The terminology has been adopted by the American Joint Committee on Cancer, separating the anal region into the anal canal, the perianal region and the skin.

Medical students' learning of anatomy: memorisation, understanding and visualisation.

Introduction: There is much subjective discussion, but few empirical data that explore how students approach the learning of anatomy.

Aims: Students' perceptions of successful approaches to learning anatomy were correlated with their own approaches to learning, quality of learning and grades.

Methods: First-year medical students (n = 97) studying anatomy at an Australian university completed an online survey including a version of the Study Process Questionnaire (SPQ) that measures approaches to learning.

Synthesis and evaluation of antimicrobial activity of novel hydrazino and N-benzylidinehydrazino-substituted 4,8-dihydro-1H,3H-pyrimido[4,5-d]pyrimidin-2,7-dithiones.

A number of novel pyrimido[4,5-d]pyrimidine-2,7-dithone derivatives bearing hydrazino and N-benzylidinehydrazino substitution were efficiently synthesized and screened for in vitro antibacterial activities against the representative panel of three Gram-positive and two Gram-negative bacteria. All the synthesized compounds showed the potent inhibitory action against Gram-positive bacteria. Particularly, N-benzylidinehydrazino-substituted compounds imparted profound effect.

Role of Dietary Intake and Biomarkers in Risk of Breast Cancer: A Case Control Study.

Reproductive factors are not considered to play a significant role in the aetiology of breast cancer in low incidence regions like Gujarat, although it is well established that they exert a major influence on such tumours in the western developed world. Women in the western Indian region have a very low prevalence of smoking, alcohol consumption but a high prevalence of vegetarianism. Noting the changes in the life style practices with increasing affluence is likely to yield several interesting findings in such a population.