Development of an assay for colorimetric and fluorometric detection of HS.

Hydrogen sulfide is a highly toxic gas that can produce extremely rapid CNS and respiratory depression and sometimes becomes fatal at high concentrations. There is no proven antidote for hydrogen sulfide poisoning. Hence, it is important to reduce the production of HS in several industries, such as oil and gas refining and mining industries.

Development of a Nanomarker for Monitoring of Dopamine in Plants.

Dopamine, alongside norepinephrine and epinephrine, belongs to the catecholamine group, widely distributed across both plant and animal kingdoms. In mammals, these compounds serve as neurotransmitters with roles in glycogen mobilization. In plants, their synthesis is modulated in response to stress conditions aiding plant survival by emitting these chemicals, especially dopamine that relieves their resilience against stress caused by both abiotic and biotic factors.

Endophytic Streptomyces sp. MSARE05 isolated from roots of Peanut plant produces a novel antimicrobial compound.

Aim: This study aimed to isolate, endophytic Streptomyces sp. MSARE05 isolated from root of a peanut (Arachis hypogaea) inhibits the growth of other bacteria. The research focused on characterizing the strain and the antimicrobial compound.

Iodine(III)-promoted oxidative carbotrifluoromethylation of maleimides with imidazopyridines and Langlois' reagent.

A metal-free protocol for oxidative carbotrifluoromethylation of maleimides with imidazopyridines and Langlois' reagent has been developed using (diacetoxyiodo)benzene (PIDA) as an oxidant. This three-component strategy enables one-step construction of 3,4-disubstituted maleimides in good yields with high functional group tolerance. Both experimental and theoretical studies support the proposed radical reaction mechanism.

Insights into colistin-mediated fluorescence labelling of bacterial LPS.

Gram-negative bacterial infections are becoming untreatable due to their ability to mutate, and the gradual development of their resistance to the available antimicrobials. In recent times colistin, a drug of last resort, started losing its efficacy towards multidrug-resistant bacterial infections. Colistin targets bacterial endotoxin lipopolysaccharides (LPS) and destabilises the cytoplasmic membrane by disrupting the outer LPS membrane.

Gene Silencing and Gene Delivery in Therapeutics: Insights Using Quantum Dots.

Hemophilia, cancer, diabetes, cardiovascular disease, mental health issues, immunological deficiencies, neuromuscular disease, blindness, and other ailments can all be treated with gene silencing and gene therapy, a growing discipline in medicine. It typically refers to a range of therapeutic techniques in which a patient's body's particular cells are given genetic material designed to correct and erase genetic flaws. The advancements in genetics and bioengineering have paved the way for the conceptualization of gene therapy through the manipulation of vectors, enabling the targeted transfer of extrachromosomal material to specific cells.

Efficient delivery of methotrexate to MDA-MB-231 breast cancer cells by a pH-responsive ZnO nanocarrier.

Methotrexate (MTX), an efficient chemotherapy medication is used in treating various malignancies. However, the breast cancer cell line MDA-MB-231 has developed resistance to it due to low levels of the MTX transport protein, and reduced folate carrier (RFC), making it less effective against these cancer cells. Here we designed a very simple, biocompatible, and non-toxic amine-capped ZnO quantum dots to overcome the MTX resistance on the MDA-MB-231 breast cancer cell line.

Differential detection of aspartic acid in MCF-7 breast cancer cells.

Aspartic acid is a non-essential amino acid obtained in the neuroendocrine tissues of vertebrates and invertebrates. Aspartic acid, a major excitatory neurotransmitter in the mammalian central nervous system, plays a key role in memory and acts in many other normal and abnormal physiological processes. In this work, we have developed an efficient chemosensor (PCF) based on the pyridine-carbazole moiety for the differential detection of aspartic acid in biological systems.

Detection of exposed phosgene in household bleach: development of a selective and cost-effective sensing tool.

Sensing of gaseous environment pollutants and health hazards is in demand these days and in this regard, lethal phosgene has emerged as a leading entrant. In this contribution, we have successfully developed a facile chemodosimeter (ANO) based on an anthracene fluorophore and oxime recognition site with an interesting mechanism to sense lethal phosgene evolved from bleaching powder, a very popular disinfectant and sanitizer. The ANO probe is highly competent in recognizing deadly phosgene in solution and in the gaseous phase with a detection limit in the nanomolar range (1.

In vivo 'turn on' fluorescence detection of free cysteine in zebrafish kidney and liver.

Cysteine is directly associated with a wide range of biological processes. Besides its essential role in protein synthesis, cysteine undergoes a variety of post-translational modifications which modulate several physiological processes. Dysregulated cysteine metabolism is associated with several neurodegenerative disorders.

Fabrication of a luminescent chemosensor for selective detection of Al used as an adjuvant in pharmaceutical drugs.

A new fluorescent chemosensor (NAN), fabricated by integrating 2-hydroxy naphthaldehyde and 1,8-naphthalic anhydride, shows high affinity for aluminium over other bio-relevant metal ions. The probe solution rapidly switched from non-fluorescent to bright blue fluorescence upon the addition of Al under a UV-lamp, possessing a remarkably low detection limit of 33 nM. The interaction mechanism between the metal ion and NAN has been well established by a number of techniques such as absorbance, fluorescence, and H NMR titration and verified by detailed theoretical calculations as well.

Cobalt-conjugated carbon quantum dots for in vivo monitoring of the pyruvate dehydrogenase kinase inhibitor drug dichloroacetic acid.

Dichloroacetic acid (DCA), an organohalide that present in environmental sample and biological systems, got high attention for its therapeutic potential as the inhibitor of pyruvate dehydrogenase kinase (PDK), elevated in obesity, diabetes, heart disease and cancer. Herein, we developed a Cobalt conjugated carbon quantum dots (N-CQDs/Co) that selectively detect DCA by fluorescence "turn-on" mechanism. Utilizing TEM, DLS, UV-vis and fluorescence spectroscopy, the mechanism has been thoroughly elucidated and is attributed to disaggregation induced enhancement (DIE).

Identification of a novel quinoline-based UV-protective pigment from a psychrotrophic Arctic bacterium.

Aims: Psychrotrophs are extremophilic microorganisms that grow optimally in low temperature having many unique bioactive molecules of biotechnological applications. In this study, we characterized a pigment from an arctic bacterium with protective activity towards UV exposure.

Methods And Results: The present research reports isolation and characterization of a psychrotrophic bacteria, RSAP2, from the soil sample of NyAlesund (78°56"N, 11°54"E), Svalbard, Norway.

The impact of MOFs in pH-dependent drug delivery systems: progress in the last decade.

Metal-organic frameworks (MOFs) are porous crystalline materials consisting of one-, two-, or three-dimensional networks created by metal ions/clusters and multidentate organic linkers through coordination bonding. MOFs are one of the most favorable candidates for biological applications such as wound dressings, cardiac prosthesis, tissue engineering, bioimaging, and drug delivery and as cancer theranostic systems due to their high surface area and porosity for the high loading of therapeutic agents and facile modification of their physical (, pore size and shape) and chemical properties. Drug delivery involves the administration of drugs using a suitable carrier for achieving treatment without unwanted side effects.

An antibacterial compound pyrimidomycin produced by Streptomyces sp. PSAA01 isolated from soil of Eastern Himalayan foothill.

Selective isolation of soil Actinobacteria was undertaken to isolate a new class of antibiotics and bioactive molecules. A Streptomyces sp. PSAA01 (= MTCC 13,157), isolated from soil of Eastern Himalaya foothill was cultivated on a large scale for the production of the antimicrobial SM02.

Reliable fluorescence technique to detect the antibiotic colistin, a possible environmental threat due to its overuse.

Colistin, considered a drug of last resort as it is effective towards multidrug-resistant Gram-negative bacterial infections. Oral administration of colistin in the poultry industry is a common practice, not only to prevent and reduce bacterial infections, but also as a rapid-growth promoter. Long-term exposure to any antibiotic will eventually lead to the development of bacterial resistance towards all antibiotics through various mechanisms in the physiological system and environment.

A handy and accessible tool for identification of Sn(II) in toothpaste.

An easily accessible colorimetric probe, a carbazole-naphthaldehyde conjugate (CNP), was successfully prepared for the selective and sensitive recognition of Sn(II) in different commercially-available toothpaste and mouth wash samples. The binding mechanism of CNP for Sn was confirmed by UV-Vis, H, and C NMR titrations. The proposed sensing mechanism was supported by quantum chemical calculations.

Luminescence turn-on response of naphthalene diimide based chemosensor with Formaldehyde: A novel stratagem for estimation of formaldehyde in storage fish samples.

A new strategy has been developed for selective estimation of toxic Formaldehyde (FA) in storage fish samples by a simple chemosensor (BNDI) based on naphthalene diimide core in aqueous medium at neutral pH. The rapid "lightning-up" fluorescence feature of BNDI has been implied to detect and estimate aqueous FA selectively at very low concentration. The chemosensing properties of BNDI with aqueous FA have been established through a unique interaction pattern which is proven by different spectroscopic and theoretical analysis.

Involvement of a unique chemodosimeter in the selective estimation of noxious cyanide in common water hyacinth (): an environmental refinement.

A naphthaldehyde-pyridoxal conjugated chemodosimeter (NPLC) was developed and employed for the sensitive and selective detection and estimation of cyanide in common water hyacinth (), a free floating macrophyte used in the phytoremediation process since ancient times. The non-fluorescent nature of the probe NPLC, directed by the possibility of excited state intramolecular proton transfer process (ESIPT), was promptly changed due to CN induced di-deprotonation of the probe. The naked eye color change and turn on vivid fluorescent color of NPLC was attributed to the inhibition of the ESIPT mechanism in the deprotonated NPLC (NPLC-D).

Prompt detection of endogenous hypochlorite (ClO) in murine macrophages and zebrafish embryos facilitated by a distinctive chemodosimetric mode.

An innovative fluorescein appended naphthalene diimide based probe (FANDI) has been prepared and characterized to selectively recognize hypochlorite or ClO ions in the presence of other reactive oxygen species (ROS) and biorelevant ions, using a unique chemodosimetric method. Hypochlorite induced oxidation can efficiently alter the initial photophysical properties of FANDI and shows an easily detectable "turn on" green fluorescence. The chemodosimeter FANDI can efficiently detect exogenous as well as endogenous ClO ions in RAW 264.

Streptomyces sp SM01 isolated from Indian soil produces a novel antibiotic picolinamycin effective against multi drug resistant bacterial strains.

A Kashmir Himalayan (India) soil isolate, Streptomyces sp. SM01 was subjected to small scale fermentation for the production of novel antimicrobials, picolinamycin (SM1). The production has been optimized which found to be maximum while incubated in AIA medium (pH 7) for 7 days at 30 °C.

Retraction: Differential detection and quantification of cyclic AMP and other adenosine phosphates in live cells.

Retraction of 'Differential detection and quantification of cyclic AMP and other adenosine phosphates in live cells' by Sujoy Das et al., Chem. Commun.

Rare Crystal Structure of Open Spirolactam Ring along with the Closed-Ring Form of a Rhodamine Derivative: Sensing of Cu Ions from Spinach.

Crystal structures of a rhodamine derivative in its closed and open spirolactam ring forms were developed, which allows selective and sensitive detection of Cu ions at a micromolar range in neutral medium. The chemosensing properties of the probe through a pentacoordinate Cu ions were proven by spectroscopic and theoretical analysis. The spirolactam ring opening as the Cu selective sensor was applied to spinach () to estimate the accumulation of copper as copper(II) in the plant.

Development of a new fluorescent probe for cysteine detection in processed food samples.

Cysteine is a crucial amino acid, found in a huge amount in protein-rich foods. We focused our research to determine the amount of free cysteine consumed highly in foods such as pork, beef, poultry, eggs, dairy, red peppers, soybeans, broccoli, brussels sprouts, oats, and wheat germs. A newly designed carbazole-pyridine-based fluorescent probe (CPI) has been introduced for quantitative estimation of cysteine (Cys) with a "turn on" fluorescence in some popular processed food samples chosen from our daily diet.