Publications by authors named "Pritesh R Mutha"
Introduction: The incremental yield of I-Scan virtual chromoendoscopy compared to high-definition white light endoscopy (HD-WLE) in detection of colorectal adenomas has not been thoroughly elucidated.
Methods: A systematic search from inception to April 2023 was conducted to identify randomized controlled trials (RCTs) comparing I-Scan to HD-WLE for detection of adenomas. A random effects model was used to compute risk difference (RD) with corresponding 95% confidence intervals in adenoma detection rate (ADR).
Baseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial.
JAMA Netw Open
July 2023
Article Synopsis
- The CONFIRM trial aimed to compare the effectiveness of annual fecal immunochemical tests (FIT) versus colonoscopies in reducing colorectal cancer mortality, enrolling over 50,000 veterans between May 2012 and December 2017.
- The study analyzed participant demographics and examined reasons for those who chose not to participate, highlighting a mix of preferences for either colonoscopy or stool tests based on geographic and temporal factors.
- Among the 50,126 participants recruited, there was a diverse representation, and the study also noted that 11,109 eligible individuals opted out of participation for various reasons, with insights gathered via case report forms.
Introduction: Epithelial barrier function (EBF) disruption is a key mechanism underlying gastroesophageal reflux disease (GERD). Our aim was to assess whether two novel technologies, probe-based confocal laser endomicroscopy (pCLE) and mucosal integrity testing (MIT), could assess EBF.
Methods: We prospectively enrolled patients undergoing upper endoscopy for refractory GERD or non-GERD conditions.
Background: In otherwise healthy patients, randomized trials have shown reduced mortality with cholecystectomy (CCY) when compared to non-operative management after endoscopic retrograde cholangiopancreatography (ERCP) for biliary stone disease. These findings may not apply to veterans with multiple comorbidities, who have an increased risk of postoperative complications.
Aims: Our study assessed the benefit of CCY among veterans with multiple comorbidities.