Publications by authors named "Pritam Panigrahi"

Background: Development of ventilator-associated pneumonia (VAP) is attributed to the microaspiration of pooled secretions around the cuff of airway devices. Despite the emphasis on the use of endotracheal tubes (ET) with subglottic secretion (SS) drainage ports to prevent VAP, the quality of the evidence for this recommendation remains moderate. This prospective observational study analyzed microbiological concordance between SS and endotracheal aspirate (ETA) cultures to generate further evidence in this regard.

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Article Synopsis
  • Recent trials suggest high-dose dexamethasone (HDD) and tocilizumab (TCZ) may help treat moderate to severe COVID-19 with ARDS, but no direct comparison had been made until this study.
  • Patients with worsening conditions were randomly assigned to receive either HDD or TCZ along with standard care, with the main goal of measuring ventilator-free days within 28 days.
  • Results showed HDD led to significantly fewer ventilator-free days and higher mortality rates, along with more secondary infections, leading to a recommendation against its use in favor of TCZ, which proved to be safer and more effective.
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