Publications by authors named "Priscilla S Chan"
We provide a comprehensive tumor-intrinsic kinome landscape that provides a roadmap for the use of kinase inhibitors in PDAC treatment approaches.
View Article and Find Full Text PDFObjective: To assess the utility of tumor-intrinsic and cancer-associated fibroblast (CAF) subtypes of pancreatic ductal adenocarcinoma (PDAC) in predicting response to neoadjuvant therapy (NAT) and overall survival (OS).
Background: PDAC remains a deadly disease with limited treatment options, and both the tumor as well as the microenvironment play an important role in pathogenesis. Gene expression-based tumor-intrinsic subtypes (classical and basal-like) have been shown to predict outcomes, but tumor microenvironment subtypes are still evolving.
Article Synopsis
- Researchers have identified distinct subpopulations of cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma using single-cell RNA sequencing, but their clinical importance was uncertain.
- They developed a classifier named DeCAF to classify CAF subtypes based on RNA sequencing data, which has been validated in various cancer types and shown to have unique histological features and prognostic value.
- DeCAF provides a reliable method to understand CAF roles in cancer, assisting in the development of targeted therapies by distinguishing between permissive and restraining CAF subtypes.
Background: Pancreatic ductal adenocarcinoma (PDAC) has a fibrotic stroma that has both tumor-promoting and tumor-restraining properties. Different types of cancer-associated fibroblasts (CAFs) have been described. Here, we investigated whether CAFs within the same subtype exhibit heterogeneous functions.
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