Publications by authors named "Priscilla Alves de Aquino"
Diversity of astacin-like metalloproteases identified by transcriptomic analysis in Peruvian Loxosceles laeta spider venom and in vitro activity characterization.
Raíssa Medina-Santos Clara Guerra-Duarte Sabrina de Almeida Lima Fernanda Costal-Oliveira Priscilla Alves de Aquino
Biochimie
December 2019
Article Synopsis
- Loxosceles spiders are prevalent in South America, particularly the Loxosceles laeta species in Peru, which is responsible for numerous venom-related accidents, earning the nickname "killer spiders."
- The study focused on analyzing the venom gland transcripts of Peruvian L. laeta using bioinformatics, specifically targeting astacin-like metalloproteases (LALPs) that play a role in venom effects.
- By constructing and sequencing a cDNA library, researchers identified nine potential LALP isoforms in L. laeta venom and validated their findings, enhancing the understanding of Loxosceles spider venom composition and function.