Publications by authors named "Priscila S S Souza"
Article Synopsis
- - The study investigates the effectiveness of photodynamic therapy (PDT) using erythrosine on oropharyngeal cancer cells (HEp-2) and aims to understand the underlying mechanisms of cell death, including apoptosis and necrosis.
- - Cytotoxicity assays showed that erythrosine's effect on cell viability was time- and concentration-dependent, with significant apoptosis occurring only under specific conditions without light, while photoactivation mainly led to necrosis at higher concentrations.
- - The research highlights that erythrosine binds to cancer cell membranes through electrostatic interactions, and light exposure enhances cell membrane changes, driving the necrotic cell death pathway observed in the experiments.
Neutrophil extracellular traps possess anti-human respiratory syncytial virus activity: Possible interaction with the viral F protein.
Virus Res
June 2018
Human respiratory syncytial virus (hRSV) is one of the main etiological agents of diseases of the lower respiratory tract, and is often responsible for the hospitalization of children and the elderly. To date, treatments are only palliative and there is no vaccine available. The airways of patients infected with hRSV exhibit intense neutrophil infiltration, which is responsible for the release of neutrophil extracellular traps (NETs).
View Article and Find Full Text PDFNeutrophils release fibrous traps of DNA, histones, and granule proteins known as neutrophil extracellular traps (NETs), which contribute to microbicidal killing and have been implicated in autoimmunity. The role of NET formation in the host response to nonbacterial pathogens is not well-understood. In this study, we investigated the release of NETs by human neutrophils upon their interaction with Trypanosoma cruzi (Y strain) parasites.
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