Publications by authors named "Priscila Neves Bernecule"
Article Synopsis
- The Barretos Cancer Hospital Animal Facility (BCHAF) in Brazil specializes in using animal models to advance cancer research.
- The facility conducts experiments involving mutant strains of mice, xenograft models, and patient-derived xenografts (PDXs).
- The research highlights both progress and challenges in creating these models to improve understanding of tumor biology and to identify potential cancer biomarkers for personalized treatment.
Introduction: Cancer of unknown primary origin (CUP) is defined as metastatic cancer without identification of the primary site. Considering that only 15-20% of patients with CUP show a favorable outcome, identifying biomarkers may help improve the clinical management of patients who do not respond well to conventional therapies. In this context, the study of the metabolic profile of CUP may pave the way to establish new biomarkers and/or therapeutic targets; therefore, this study aimed to characterize the expression of metabolism-related proteins in CUP.
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