Publications by authors named "Priscila Del S Lopez-Castillo"
Safety and Tolerability of Six Months of Isoniazid Plus Pyridoxine or Three Months of Rifampicin for Tuberculosis among Subjects with Diabetes Mellitus: A Randomized Trial.
Karla M Tamez-Torres Norma Mongua-Rodríguez Leticia Ferreyra-Reyes Pedro Torres-Gonzalez Guadalupe Delgado-Sánchez
Microorganisms
July 2023
Article Synopsis
- Tuberculosis (TB) is increasing among people with diabetes mellitus (DM), especially in lower-resource countries.
- A trial in Mexico City tested TB preventive treatments using isoniazid (INH) and rifampicin (RIF) in individuals with type 2 DM, involving 130 participants.
- The study was halted due to safety concerns; while the overall adverse event rates were similar, more participants on INH faced serious liver issues, while those on RIF had severe gastrointestinal problems, suggesting that neither treatment is safe enough for routine use in this population.