Publications by authors named "Prisca Baah Nketia"
Article Synopsis
- * This study examines how halogenated phenazine compounds can disrupt AgrA's function using methods like molecular docking and dynamics simulation, revealing strong binding affinities that hinder AgrA's ability to bind DNA.
- * Findings suggest that these compounds effectively inhibit biofilm formation by altering AgrA's structure and interactions, laying the groundwork for drug development focused on targeting the AgrA-DNA relationship in future research.
Despite the recent advances in drug research, finding a safe, effective, and easy to use chemotherapy for human African trypanosomiasis (HAT) remains a challenging task. Trypanosomatids have developed resistance mechanisms towards melarsoprol (the current drug of choice), and the fact that it is poisonous is problematic. Therefore, a search for alternative therapeutics against the parasite is urgently needed.
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