The Effect of Early Versus Late Amniotomy on The Course of Labor.

Objective: Comparison effect of early versus late amniotomy on the duration time of first and second stage of labor, the cesarean section rate and analgesic use during labor.

Study Design: Randomized control trial study.

Setting: Labor unit, Department of Obstetrics and Gynecology, Phramongkutklao Hospital.

Effectiveness of the model for prenatal control of severe thalassemia.

Objective: The aim of the research was to determine effectiveness of the model for prenatal control in reducing new cases of severe thalassemia.

Methods: Pregnant women at six tertiary centers were recruited to follow the model, consisting of (1) carrier screening using mean corpuscular volume (for alpha-thal-1 and beta-thal) and CMU-E screen (for HbE trait), (2) carrier diagnosis, (3) the couples at risk were counseled and offered prenatal diagnosis, and (4) termination of affected pregnancy. All neonates were evaluated for thalassemia.

Causes and attitude of husbands toward thalassemic carrier screening test when their partners have abnormal screening tests.

Objective: To assess the attitude of husbands toward the thalassemic carrier screening test and to explore the causes of non-participation of having a blood test.

Study Design: Descriptive study.

Material And Method: During 2007-2008, 100 husbands of pregnant women with screening-positive test for thalassemia who refused to have blood test were enrolled by voluntariness.

Effectiveness of paracervical block versus intravenous morphine during uterine curettage: a randomized controlled trial.

Background: Abnormal uterine bleeding is a common gynecologic problem. Fractional curettage, evacuation and curettage, and dilatation curettage are common gynecologic procedures for investigation and treatment of abnormal uterine bleeding. To perform all these procedures, anesthesia is needed but technique varies among hospitals.

The Xp contiguous deletion syndrome and autism.

Xp22 nullisomy in males causes a phenotype consistent with the loss of one or more of the genes located in this chromosomal region. Females with similar Xp deletions rarely manifest the same phenotype. Here we describe a 10-year-old girl with a de novo interstitial deletion encompassing Xp22.

The association between meconium-stained amniotic fluid and chorioamnionitis or endometritis.

Objective: Assess the association between meconium-stained amniotic fluid and chorioamnionitis or endometritis in term pregnant women.

Material And Method: A five-year retrospective study was undertaken between January 1, 1999 and December 31, 2003. One thousand seventy-nine pregnant women who delivered at the Department of Obstetrics & Gynecology, Phramongkutklao Hospital were included in the present study.

Cost-effectiveness analysis of various screening methods for osteoporosis in perimenopausal Thai women.

Objective: To perform a health economics analysis of 5 screening programs for osteoporosis in perimenopausal Thai women comparing two alternatives; without intervention and universal treatment without screening.

Design: A decision analysis was performed to evaluate five screening strategies: Dual energy X-ray absorptiometry (DXA), Quantitative ultrasound sonography (QUS), risk index (clinical risk factors), two-step screening with QUS followed by DXA, and screening with risk index followed by DXA, comparing outcomes without intervention and universal treatment without screening.

Results: The costs for universal treatment, screening by DXA with treatment, screening by QUS with treatment, screening by Risk index with treatment, screening by QUS and DXA with treatment, and screening by Risk index and DXA with treatment strategies to prevent one fracture were 207.

Recurrent biparental hydatidiform mole: additional evidence for a 1.1-Mb locus in 19q13.4 and candidate gene analysis.

Objectives: A maternal autosomal recessive mutation causing recurrent biparentally inherited complete hydatidiform moles (BiCHM) in affected women was previously mapped to a 12.4-cM interval in 19q13.4, which was recently further narrowed to a smaller 1.

Presence of filamin in the astrocytic inclusions of Aicardi syndrome.

Aicardi syndrome affects only females and has been hypothesized to be an X-linked dominant male-lethal disorder. Because no familial cases can be studied for genetic linkage analysis, the mutated gene has remained elusive. With the goal of selecting genes for mutation analysis by a functional candidate approach, a detailed pathologic analysis of two brains from deceased Aicardi syndrome patients was performed.