Corrigendum: What can the common fruit fly teach us about stroke?: lessons learned from the hypoxic tolerant .

[This corrects the article DOI: 10.3389/fncel.2024.

What can the common fruit fly teach us about stroke?: lessons learned from the hypoxic tolerant .

Stroke, resulting in hypoxia and glucose deprivation, is a leading cause of death and disability worldwide. Presently, there are no treatments that reduce neuronal damage and preserve function aside from tissue plasminogen activator administration and rehabilitation therapy. Interestingly, , the common fruit fly, demonstrates robust hypoxic tolerance, characterized by minimal effects on survival and motor function following systemic hypoxia.

Progesterone from maternal circulation binds to progestin receptors in fetal brain.

Steroid hormones activate nuclear receptors which, as transcription factors, can regulate critical aspects of neural development. Many regions of the rat forebrain, midbrain and hindbrain express progestin receptors (PR) during perinatal life, suggesting that progesterone may play an important role in the development of the brain. An immunohistochemical approach using two antibodies with differential recognition of ligand-bound PR was used to examine whether fetuses are exposed to maternal progesterone during pregnancy and whether progesterone from maternal circulation can bind to PR within the fetal brain.

Progesterone receptor expression in the brain of the socially monogamous and paternal male prairie vole.

Differences in the social organization and behavior of male mammals are attributable to species differences in neurochemistry, including differential expression of steroid hormone receptors. However, the distribution of progestin receptors (PR) in a socially monogamous and spontaneously parental male rodent has never been examined. Here we determined if PR exists and is regulated by testicular hormones in forebrain sites traditionally influencing socioreproductive behaviors in male prairie voles (Microtus ochrogaster).