Publications by authors named "Princesse Paku-Tshambu"
Recent reports raise concerns on the changing epidemiology of mpox in the Democratic Republic of the Congo (DRC). High-quality genomes were generated for 337 patients from 14/26 provinces to document whether the increase in number of cases is due to zoonotic spillover events or viral evolution, with enrichment of APOBEC3 mutations linked to human adaptation. Our study highlights two patterns of transmission contributing to the source of human cases.
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- Between January and August 2024, nearly all provinces of the Democratic Republic of the Congo reported cases of mpox.
- Genome sequencing from 11 cases in Kinshasa revealed the presence of two subclades, Ia and Ib, co-circulating in the Limete health zone.
- Phylogenetic analyses indicated that these subclades have multiple introductions in Kinshasa, highlighting the increasing complexity of mpox outbreaks in the DRC.