Diversity and Ethno-Mycopharmacological Insights of Medicinal Mushrooms of the Bangus Valley of Jammu and Kashmir, India.

The present study was carried out in various regions of Jammu and Kashmir, India, for the diversity and pharmacology of wild mushrooms. The valley is bestowed with alpine meadows and dense coniferous forest. Because of its isolation, security concerns, and line of control, most of these locations either have been little investigated or are entirely undiscovered.

Synthesis, characterization, antiamoebic activity and toxicity of novel bisdioxazole derivatives.

Cyclization of benzene-1,4-dicarbaldehyde dioxime 1 with different aromatic aldehydes in inert atmosphere yielded the corresponding new bisdioxazoles 2-11. The structure of 2-11 was elucidated by spectral data. In vitro antiamoebic activity was performed against HM1:IMSS strain of Entamoeba histolytica.

Antiamoebic coumarins from the root bark of Adina cordifolia and their new thiosemicarbazone derivatives.

In continuation of our search for potential antiamoebic agents from folklore Indian medicinal plants, we found that the benzene and ethyl acetate extracts from the root bark of Adina cordifolia exhibited strong antiamoebic activity with IC(50) values of 2.92 and 2.50 microg/ml, respectively.

Synthesis and in vitro antibacterial activity of new steroidal thiosemicarbazone derivatives.

We investigated the antibacterial activity of some new steroidal thiosemicarbazone derivatives, prepared from the reaction of cholest-5-en-7-one with thiosemicarbazides, in ethanol in the presence of a few drops of HCl at 80 degrees C in high yield. All the compounds have been characterized by means of elemental analyses, IR, 1H NMR and mass spectroscopic data, to find an effective antibacterial agent. The antibacterial activity was first tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) of compounds was determined.