Publications by authors named "Primrose Songoro"
Lancet Haematol
April 2023
Article Synopsis
- Transcranial Doppler screening is effective in reducing stroke risk in children with sickle cell anemia, but it’s impractical in low-resource areas, prompting a study on hydroxyurea as a treatment alternative in Tanzania.
- An open-label phase 2 trial (SPHERE) was conducted at Bugando Medical Centre, enrolling children aged 2-16 with confirmed sickle cell anemia, focusing on the drug hydroxyurea to lower stroke risk after undergoing Doppler screening.
- Out of 202 enrolled children, 24% had elevated Doppler velocities, and the primary goal was to assess changes in these velocities after 12 months of hydroxyurea treatment, with safety analyzed in participants who
Article Synopsis
- Local healthcare workers screened children aged 2-16 for stroke risk using Transcranial Doppler (TCD) ultrasonography, determining eligibility for hydroxyurea treatment based on their screening results.
- The trial has shown a high prevalence of stroke risk indicators and splenomegaly among participants, with expectations to evaluate the benefits of hydroxyurea and increase access to treatment in Tanzania.
