Alpha-Mangostin Partially Preserves Expression of Ammonia-Metabolizing Enzymes in Thioacetamide-Induced Fibrotic and Cirrhotic Rats.

Background: Ammonia metabolizing enzymes, carbamyol phosphate synthetase (CPS) and glutamine synthetase (GS), are expressed in the periportal and pericentral hepatocytes, respectively. CPS and GS function complementary to ensure complete ammonia detoxification. Immunohistochemical analysis confirmed the decline of both CPS and GS in cirrhotic rat liver induced by thioacetamide (TAA).