Mathematical model of the cell cycle regulation in budding yeasts.

A mathematical model of the cell cycle regulation in S. cerevisiae is proposed. The model is based on the assumption of the G1----S phase transition control mediated by two signals.

A mathematical model of extracorporeal antibody removal in autoimmune disease.

A mathematical model of T-B cell cooperation is adopted to describe autotolerance and autoimmunity. The model describes the development of plasma cells and T-helper cells from their precursors through activated and proliferating cells. A state of autotolerance is simulated by reducing the rate of T precursors supply (partial clonal deletion theory), while the normal rate yields a stable state of autoimmunity.

Autoimmunity and its therapy: mathematical modelling.

A mathematical description of autotolerance and autoimmunity based on the previous model of immune response for normal antigen stimulation is given. In particular, the clonal deletion theory and non-specific stimulation of T-helper cells are included. Thus, an idea about the origin of autoimmune disease and the qualitative description of its course is presented.

A new mathematical model of proliferation control during immune response.

A considerable proliferation of participating cells is a characteristic feature of the immune response. This proliferation may be controlled by Interleukin 2. Assumptions on the course of the immune response under such a control are formulated, and a new mathematical model of the immune response involving regulation of the proliferation of appropriate cells is constructed.

The X----Y----Z scheme after 23 years.

Mathematical modelling of the course of the immune response is undoubtedly one of the most progressive and most promising areas of modern immunology. Mathematical models (along with computer programs) can be taken as "the only means of thoroughly testing and examining a large and intricate theory" (Partridge et al. 1984).

Establishment of a macrophage hybrid population by the fusion of mouse peritoneal macrophages with thymoma cells BW5147.

A continuous macrophage hybrid population, designated MBW-1, was produced by the fusion of peritoneal macrophages from a normal AKR mouse with thymoma cells BW5147. The hybrid cells are resistant to HA selection medium. In their nearly triploid chromosome complement they carry metacentric chromosomes typical of BW5147 cells and express the typical macrophage-like characteristics (morphology of macrophages, adherence properties, phagocytosis, expression of macrophage-specific antigen and receptor for the C3b component of complement).

Phagocytosis of 2-hydroxyethylmethacrylate copolymer particles by different types of macrophages.

Phagocytic activity (for 2-hydroxyethylmethacrylate particles) in normal and thioglycollate- or proteose peptone-stimulated peritoneal macrophages, Peyer's patches macrophages, bone marrow macrophages and macrophage-like cell lines BWM, DCH 5, PU-5-lR and RAW 264.7, in suspension and after adherence to a substrate, was tested. Results of testing showed that 2-hydroxyethylmethacrylate particles are advantageous for following the phagocytic activity of the above cell types.