Publications by authors named "Prieur C"

Background: Temporary transvenous pacing (TTP) is a common procedure, predominantly performed in the catheterization laboratory (cath lab) because of presumed lower complication rate. This study aims to evaluate the efficacy and safety of TTP placement in the ICU compared to TTP placement in the cath lab.

Methods: This retrospective, real-life study included all patients requiring TTP in a tertiary care ICU between 2019 and 2022.

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  • RANTES (CCL5) is a chemokine involved in immune response and may play a role in diseases like atherosclerosis, but its importance during acute myocardial infarction (MI) is not well understood.
  • The study analyzed 250 patients with ST-segment-elevation MI, tracking serum levels of RANTES over time and its correlation with major adverse cardiovascular events during a 12-month follow-up.
  • Results showed that lower levels of RANTES were linked to a higher risk of major adverse cardiovascular events, suggesting that post-MI RANTES levels could serve as a useful prognostic marker for patients.
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  • The study investigates the role of IL-6 and MCP-1 cytokines, along with the STAT3 signaling pathway, in recruiting and activating macrophages during heart attacks (STEMI) using both human and mouse models.
  • Cardiac cells release these cytokines under low oxygen conditions, leading to the activation of anti-inflammatory macrophages through the STAT3 pathway.
  • The research finds that blocking IL-6, MCP-1, or the STAT3 pathway can decrease heart damage after a heart attack, suggesting that these anti-inflammatory macrophages may have negative effects in the early stages of STEMI.
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Transcatheter aortic valve replacement (TAVR) has emerged as a viable treatment for aortic valve disease, including low-risk patients. However, as TAVR usage increases, concerns about long-term durability and the potential for addition interventions have arisen. Transcatheter aortic valve (TAV)-in-TAV procedures have shown promise in selected patients in numerous registries, offering a less morbid alternative to TAVR explantation.

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Aim: This work explores the experiences and meaning attributed by parents who underwent the decision-making process of withholding and/or withdrawing life-sustaining treatment for their newborn.

Methods: Audio-recorded face-to-face interviews were led and analysed using interpretative phenomenological analysis. Eight families (seven mothers and five fathers) whose baby underwent withholding and/or withdrawing of life-sustaining treatment in three neonatal intensive care units from two regions in France were included.

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In this paper, we present a spatialized extension of a SIR model that accounts for undetected infections and recoveries as well as the load on hospital services. The spatialized compartmental model we introduce is governed by a set of partial differential equations (PDEs) defined on a spatial domain with complex boundary. We propose to solve the set of PDEs defining our model by using a meshless numerical method based on a finite difference scheme in which the spatial operators are approximated by using radial basis functions.

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Ventricular septal rupture (VSR) is a serious complication of ST-elevation myocardial infarction (STEMI) and surgery is the reference treatment. We aimed at describing trends in management and mortality during the last four decades and reporting mortality predictors in these patients. We conducted a single-center retrospective study of patients sustaining a VSR from 1981 to 2020.

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As inflammation following ST-segment elevation myocardial infarction (STEMI) is both beneficial and deleterious, there is a need to find new biomarkers of STEMI severity. We hypothesized that the circulating concentration of the soluble tumor necrosis factor α receptors 1 and 2 (sTNFR1 and sTNFR2) might predict clinical outcomes in STEMI patients. We enrolled into a prospective cohort 251 consecutive STEMI patients referred to our hospital for percutaneous coronary intervention revascularization.

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  • This study investigated if colchicine, an anti-inflammatory medication, could reduce heart damage and remodeling after a ST-segment-elevation myocardial infarction (a type of heart attack) by comparing it to a placebo in a double-blind trial.
  • The trial included 192 patients, with no significant differences in heart damage or remodeling observed between the colchicine and placebo groups at both 5 days and 3 months post-treatment.
  • However, patients taking colchicine experienced higher rates of gastrointestinal side effects compared to those on the placebo, suggesting a potential drawback of the treatment.
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We report on the process and design of our visual analytics graph analysis challenge winning entry. Specifically, our team addressed the IEEE VAST 2020 Mini-Challenge 1 that asked participants to identify a group of people that accidentally caused an internet outage. To identify this group, we were given a network profile and a large multivariate social network to search in.

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  • Inflammatory processes significantly worsen myocardial damage during ischemia-reperfusion injury in STEMI, leading to serious complications like heart failure and poor recovery.
  • Colchicine, known for its strong anti-inflammatory effects, has shown a promising 50% reduction in infarct size in a phase II trial, compared to placebo, for acute STEMI patients undergoing primary percutaneous coronary intervention (PPCI).
  • The ongoing COVERT-MI trial aims to confirm these findings by comparing a short course of colchicine treatment to placebo in STEMI patients, measuring infarct size and other cardiac health indicators over 5 days.
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Background: Soluble vascular cell adhesion molecule-1 (sVCAM-1) is a biomarker of endothelial activation and inflammation. There is still controversy as to whether it can predict clinical outcome after ST-elevation myocardial infarction (STEMI). Our aim was to assess the sVCAM-1 kinetics and to evaluate its prognostic predictive value.

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Introduction: Myocardial hemorrhage (IMH) and persistent microvascular obstruction (MVO) are associated with impaired myocardial recovery and adverse clinical outcomes in STEMI patients. However, their relationship with circulating inflammatory biomarkers is unclear in human patients.

Methods And Results: Twenty consecutive patients referred for primary percutaneous coronary intervention of first STEMI were included in a prospective study.

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This paper proposes an advanced solution to improve the inertial velocity estimation of a rigid body, for indoor navigation, through implementing a magnetic field gradient-based Extended Kalman Filter (EKF). The proposed estimation scheme considers a set of data from a triad of inertial sensors (accelerometer and gyroscope), as well as a determined arrangement of magnetometers array. The inputs for the estimation scheme are the spatial derivatives of the magnetic field, from the magnetometers array, and the attitude, from the inertial sensors.

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An extension of the classical pandemic SIRD model is considered for the regional spread of COVID-19 in France under lockdown strategies. This compartment model divides the infected and the recovered individuals into undetected and detected compartments respectively. By fitting the extended model to the real detected data during the lockdown, an optimization algorithm is used to derive the optimal parameters, the initial condition and the epidemics start date of regions in France.

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Background: Oral mineralocorticoid receptor antagonists have failed to prove their efficacy for decongestion and potassium homeostasis in acute heart failure. Intravenous mineralocorticoid receptor antagonists have yet to be studied.

Aim: The aim of this study was to confirm the safety of high-dose potassium canrenoate in association with classic diuretics in acute heart failure.

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Background: Coronavirus disease 2019 (COVID-19) is likely to have significant implications for the cardiovascular care of patients. In most countries, containment has already started (on 17 March 2020 in France), and self-quarantine and social distancing are reducing viral contamination and saving lives. However, these considerations may only be the tip of the iceberg; most resources are dedicated to the struggle against COVID-19, and this unprecedented situation may compromise the management of patients admitted with cardiovascular conditions.

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Background And Purpose: Access to evidence-based mental health care for children is an international priority. However, there are significant challenges to advancing this public health priority in an efficient and equitable manner. The purpose of this international colloquium was to convene a multidisciplinary group of health researchers to build an agenda for addressing disparities in mental health care access and treatment for children and families through collaboration among scholars from the United States and Europe engaged in innovative implementation science and mental health services research.

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Among adolescents, heavy video game use and socializing online may be valued socially by peers, depending on gender and age, which can increase life satisfaction. However, heavy video gaming may also be linked to symptoms of Internet Gaming Disorder, which can decrease life satisfaction. Overall, when symptoms of Internet Gaming Disorder are present, do subjects experience decreased or increased life satisfaction, all other things being equal? The aim of this study was to explore the association between Internet Gaming Disorder symptoms and life satisfaction, while controlling for gender, age, and other conditions that may impact life satisfaction.

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Background: Recently, it was shown that interleukin-17A (IL-17A) is involved in the pathophysiology of reperfusion injury and associated with infarct size (IS) in experimental models of myocardial infarction. Our aim was to evaluate whether the IL-17A serum level and the IL-17A active fraction was correlated with IS in humans.

Methods: 101 patients presenting with a ST-elevated Myocardial Infarction (STEMI) referred for primary percutaneous coronary intervention (PPCI) and 10 healthy controls were included.

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Background: Cardiac failure is still a leading cause of death in drug intoxication. Extracorporeal life support (ECLS) could be used as a rescue therapeutic option in patients developing refractory cardiogenic shock or cardiac arrest. The aim of this report is to present our results of ECLS in the setting of poisoning from cardiotoxic drugs.

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