Intradermal electrical stimulation of sudomotor nerves and local sweat rate.

The local sweat rate (LSR) response to intradermal electrical stimulation generates a sigmodal stimulus-response curve with a peak sweat rate generated during a 30 s period of continuous stimuli at a frequency of 16 to 32 Hz. However, the firing pattern of the sudomotor nerve resembles more of a bursting pattern. We tested the hypothesis that a bursting pattern during intradermal electrical stimulation would result in a greater sweating response than the regular continuous stimulus pattern.

The impact of using cannabis during pregnancy on the infant and mother: An overview of systematic reviews, evidence map, targeted updates, and de novo synthesis.

Background: Cannabis use during pregnancy is becoming more prevalent. While numerous studies have explored the relationship of cannabis use during pregnancy and outcomes for mothers and infants, uncertainty remains regarding the impact of cannabis use on pregnancy complications and later-life outcomes for offspring.

Aims: To produce a summary of the short and long-term effects of prenatal cannabis exposure on fetal growth and development, neonatal conditions, later-life, and maternal outcomes.

Immediate Effects of Mindful Awareness in Body-Oriented Therapy as an Adjunct to Medication for Opioid Use Disorder.

Unlabelled: The need for improve medication for opioid use disorder (MOUD) treatment outcomes can be limited by co-occurring polysubstance use, mental health, and chronic pain conditions. Interoceptive training may facilitate well-being and support medication treatment for MOUD.

Objectives: While effective, medication for opioid use disorder (MOUD) treatment outcomes can be limited by co-occurring polysubstance use, mental health, and chronic pain conditions.

Inhibition and evasion of neutrophil microbicidal responses by .

Unlabelled: species evade degradation and proliferate within alveolar macrophages as an essential step for the manifestation of disease. However, most intracellular bacterial pathogens are restricted in neutrophils, which are the first line of innate immune defense against invading pathogens. Bacterial degradation within neutrophils is mediated by the fusion of microbicidal granules to pathogen-containing phagosomes and the generation of reactive oxygen species (ROS) by the phagocyte NADPH oxidase complex.

The Incidence, Aetiology and Clinical Course of Serious Infections Complicating Biological and Targeted Synthetic Disease-Modifying Antirheumatic Drug Therapy in Patients with Rheumatoid Arthritis in Tropical Australia.

: Patients receiving biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) for rheumatological conditions are at an increased risk of serious, potentially life-threatening, infection. However, the incidence, aetiology, and clinical course of serious infection in patients receiving b/tsDMARDs in tropical settings are incompletely defined. : We retrospectively reviewed all patients with rheumatoid arthritis receiving b/tsDMARDs between October 2012 and October 2021, at Cairns Hospital in tropical Australia.

Global Data Compilation Across Climate Gradients Supports the Use of Common Allometric Equations for Three Transatlantic Mangrove Species.

Predicting the distribution, structure, and biomass of mangrove forests is an area of high research interest. Across the Atlantic East Pacific biogeographic region, three species are common and abundant members of local mangrove communities; , , and . Biomass prediction for these species has relied on two approaches: site-specific allometries based on the idea that environmental/climatic differences between sites drive growth differences, or the use of common allometric equations based on the idea that site driven differences are minimal.

Developing a Carotid Pseudoaneurysm Model in Swine.

Background: Traumatic carotid artery pseudoaneurysms (PSAs) represent a vascular anomaly with potential for serious complications, including stroke. Traditional treatments involve endovascular stenting, which may not be ideally suited to otherwise healthy vessels that have the potential to remodel. Given the limitations of smaller animal models in replicating human vasculature and the need for improved treatment modalities, this study introduces a novel swine model for the creation and evaluation of carotid PSAs.

Biochar in the UK Print News Media: Issue Frames and Their Implications for Opening up Debate About Land-based Greenhouse Gas Removal.

Biochar is a land-based greenhouse gas removal technology with potential to address the climate crisis. This article examines societal debate and discussion around biochar as represented in the UK print news media and reflects on its implications for the democratic governance of novel technologies. Using an "issue frame" analysis approach, the following frames are identified - Innovation, Economics, Security, Governance and Accountability, Risk, Justice, Substitution, Salvation and Tradition - with some more prominent than others.

Predicting and Accelerating Nanomaterial Synthesis Using Machine Learning Featurization.

Materials synthesis optimization is constrained by serial feedback processes that rely on manual tools and intuition across multiple siloed modes of characterization. We automate and generalize feature extraction of reflection high-energy electron diffraction (RHEED) data with machine learning to establish quantitatively predictive relationships in small sets (∼10) of expert-labeled data, saving significant time on subsequently grown samples. These predictive relationships are evaluated in a representative material system (WVSe on c-plane sapphire (0001)) with two aims: 1) predicting grain alignment of the deposited film using pregrowth substrate data and 2) estimating vanadium dopant concentration using in situ RHEED as a proxy for ex situ methods (e.

Coding and non-coding variants in the ciliopathy gene CFAP410 cause early-onset non-syndromic retinal degeneration.

Inherited retinal degenerations are blinding genetic disorders characterized by high genetic and phenotypic heterogeneity. In this retrospective study, we describe sixteen families with early-onset non-syndromic retinal degenerations in which affected probands carried rare bi-allelic variants in CFAP410, a ciliary gene previously associated with recessive Jeune syndrome. We detected twelve variants, eight of which were novel, including c.

Associations between amyloid-β load and cognition in cerebrovascular disease beyond cerebral amyloid angiopathy: a systematic review and meta-analysis of positron emission tomography studies.

Background: There is growing interest in the comorbidity of vascular and neurodegenerative pathologies in patients with cerebrovascular disease (CVD) beyond cerebral amyloid angiopathy (CAA). However, the relationship between amyloid-β and vascular cognitive impairment (VCI) remains debated.

Objective: To investigate the association between VCI and amyloid-β deposition in non-CAA CVD patients.

Spatial Aggregations of the Grey Field Slug Are Unstable Under Abnormally High Soil Moisture Conditions.

in arable fields display spatio-temporally stable slug patches that have been well documented under typical soil moisture conditions. The effect of abnormally high soil moisture on slug patch stability, however, is unknown. In this study, stepped gradient choice tests comparing soil moisture levels of 50-125% soil capacity showed slug preferences for levels in a range near to 125%.

Designing a framework for curriculum building in systematic review competencies for librarians: a case report.

Background: Librarians play an important role on systematic review teams because of their expertise in information organization, database searching, and records management. Many systematic review training opportunities exist, but not all are tailored to the needs of librarians. The Medical Library Association, along with a workgroup of experts on systematic reviews and review services, developed a Systematic Review Services Specialization (SRSS) that was launched in 2022.

A Case of Acute Hypertriglyceridemia-Induced Pancreatitis in Pregnancy and Its Clinical Implications.

Acute hypertriglyceridemia-induced pancreatitis (HTGP) is an uncommon occurrence during pregnancy. Prompt diagnosis and initiation of treatment are indicated to prevent adverse maternal and neonatal outcomes. We present the case of a pregnant female who was diagnosed with HTGP at 34 weeks gestation and subsequently developed diabetic ketoacidosis (DKA) and preeclampsia with severe features.

Effect of teleneurology on door-to-needle times for tenecteplase in acute ischemic stroke.

Introduction: Intravenous thrombolysis remains the primary treatment for acute ischemic stroke (AIS); however, administration is time sensitive. Teleneurology services have increased in popularity in recent years due to their ability to aid in triaging patients with neurological conditions. Teleneurology services were implemented at this comprehensive stroke center, in August 2023 to aid in streamlining the administration of tenecteplase in AIS patients.