Combined effects of and on ameliorating cisplatin-induced nephrotoxicity in Swiss albino mice.

and are renowned for their medicinal properties and rich antioxidant content. These plants have been integral to Ayurvedic medicine, treating various ailments for centuries. The present study investigated the nephroprotective effects of aqueous methanolic extracts of and in a Cisplatin-induced rodent model.

Local inventories for effective management of alien species: insights from the alien flora of Jammu, Kashmir, and Ladakh, India.

The broad-scale inventories of alien species reveal macroecological patterns, but these often fall short in guiding local-level management strategies. Local authorities, tasked with on-the-ground management, require precise knowledge of the occurrence of invasive species tailored to their jurisdictional boundaries. What proves critical at the local scale may not hold the same significance at national or regional levels.

Rapid Sterilization of Clinical Apheresis Blood Products using Ultra-High Dose Rate Radiation.

Background And Objectives: Apheresis platelets products and plasma are essential for medical interventions, but both still have inherent risks associated with contamination and viral transmission. Platelet products are vulnerable to bacterial contamination due to storage conditions, while plasma requires extensive screening to minimize virus transmission risks. Here we investigate rapid irradiation to sterilizing doses for bacteria and viruses as an innovative pathogen reduction technology.

Flash flood dynamics in the foothills of the NW Himalayas: insights into hydrological and morphological controls.

The Himalayas experiences several cloudburst events due to its varied physiographical, geomorphological, and geological conditions and high rainfall. Uttarakhand is one of the Indian states circumscribed by the Himalayan ranges and has experienced a rise in the number of cloudburst catastrophes in the last few decades. These events cause substantial loss of life and property; however, very few studies have characterized these unpredictable cloudburst-induced flash floods in different regions of Uttarakhand.

Comparative efficacy of Ayurveda treatment regimen and Letrozole along with Yoga module in the management of unexplained and anovulatory female infertility; study protocol for a randomized controlled trial.

Introduction: Infertility is a significant health problem with psycho-social burden for couples. Ayurveda considers a holistic approach, including complex multimodal regimens in managing infertility. Increasing evidence has shown that Yoga as an adjuvant to infertility treatment increases pregnancy rates.

Exploring the Mediating Role of Student Attitudes in the Relationship between Dysfunctional Teams and Student Team Performance.

Recognizing the factors that cause dysfunction within a team is crucial for many teams. Growing studies have investigated the factors that affect college students' performance. This study focuses on the association between dysfunctional teams and student team performance (TP), with the mediating effect of students' attitudes towards team assessment.

Electroredox N-Heterocyclic Carbene-Catalyzed Enantioselective (3 + 3) Annulation of Enals with 2-Naphthols.

Developing asymmetric transformations using electroredox and N-heterocyclic carbene (NHC)-catalyzed radical pathways is still desirable and challenging. Herein, we report an iodide-promoted β-carbon activation (LUMO-lowering process) of enals via electroredox carbene catalysis coupled with a hydrogen evolution reaction (HER). This strategy offers an environmentally friendly and sustainable route for rapidly assembling synthetically useful chiral naphthopyran-3-one in good to excellent yield and enantioselectivity using traceless electrons as inexpensive and greener oxidants.

Physiological and emotional assessment of college students using wearable and mobile devices during the 2020 COVID-19 lockdown: An intensive, longitudinal dataset.

This dataset was collected from university students before, during, and after the COVID-19 lockdown in Southern California. Data collection happened continuously for the average of 7.8 months (=3.

Bioethanol production from potatoes in India: A SWOT analysis.

India is the third-largest energy consumer globally, heavily reliant on imported oil. Projections suggest India's energy consumption will double by 2050, posing challenges to energy security and leading to significant foreign currency outflows. The extensive use of fossil fuels increases carbon emissions, raising environmental and health concerns.

Locus coeruleus MRI contrast, cerebral perfusion, and plasma Alzheimer's disease biomarkers in older adults.

The locus coeruleus (LC) is among the first brain structures impacted by Alzheimer's disease (AD), and noradrenergic denervation may contribute to early neurovascular dysfunction in AD. Mechanistic links between the LC and cerebral perfusion have been demonstrated in rodents, but there have been no similar studies in aging humans. Community-dwelling older adults with no history of stroke or dementia (N=66) underwent structural (T1-MPRAGE; T1-FSE) and perfusion (resting pCASL) MRI.

Identification of CAP genes in finger lime (Citrus australasica) and their role in plant responses to abiotic and biotic stress.

The study focuses on the in silico analysis of cysteine-rich secretory proteins and PR1-like (CAP) genes in finger lime (Citrus australasica), a citrus species known for its tolerance to Huanglongbing (HLB). We identified several PR1-like genes, all belonging to the CRISP family within the CAP superfamily. Of them, CaCAP2 transcript levels increased by over 300-fold in the finger lime compared to 'Valencia' sweet orange upon infection with 'Candidatus Liberibacter asiaticus' (CaLas).

Biphasic DNA damage and non-canonical replication stress response govern radiation-induced senescence in glioblastoma.

Therapy-induced senescence (TIS) in glioblastoma (GBM) residual disease and escape from TIS account for resistance and recurrence, but the mechanism of TIS manifestation remains obscure. Here, we demonstrate that replication stress (RS) is critical for the induction of TIS in residual cells by employing an in vitro GBM therapy-resistance cellular model. Interestingly, we found a 'biphasic' mode of DNA damage after radiation treatment and reveal that the second phase of DNA damage arises majorly in the S phase of residual cells due to RS.

Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits.

Introduction: Older adults with mild cognitive impairment (MCI) exhibit deficits in cerebrovascular reactivity (CVR), suggesting CVR is a biomarker for vascular contributions to MCI. This study examined if spontaneous CVR is associated with MCI and memory impairment.

Methods: One hundred sixty-one older adults free of dementia or major neurological/psychiatric disorders were recruited.

Cerebral perfusion and amyloidosis in the oldest-old.

Introduction: In a nested case-control study, we examined how cerebral perfusion relates to cognitive status and amyloid in the oldest-old (i.e., 90 years of age and older).

QSOX1 Modulates Glioblastoma Cell Proliferation and Migration In Vitro and Invasion In Vivo.

: Quiescin Sulfhydryl Oxidase 1 (QSOX1) is an enzyme that catalyzes the oxidation of free thiols to generate disulfide bonds in a variety of proteins, including the cell surface and extracellular matrix. QSOX1 has been reported to be upregulated in a number of cancers, and the overexpression of QSOX1 has been correlated with aggressive cancers and poor patient prognosis. Glioblastoma (GBM) brain cancer has been practically impossible to treat effectively, with cells that rapidly invade normal brain tissue and escape surgery and other treatment.

PARylation of GCN5 by PARP1 mediates its recruitment to DSBs and facilitates both HR and NHEJ Repair.

Efficient DNA double strand break (DSB) repair is necessary for genomic stability and determines efficacy of DNA damaging cancer therapeutics. Spatiotemporal dynamics and post-translational modifications of repair proteins at DSBs dictate repair efficacy. Here, we identified a non-canonical function of GCN5 in regulating both HR and NHEJ repair post genotoxic stress.

Comparison of gait deviation index (GDI) and gait variability index (GVI) measured by marker-based and markerless motion capture systems in children with cerebral palsy (CP).

Background: The Gait Deviation Index (GDI) is a metric clinicians use to assess overall gait pathology in children with cerebral palsy (CP) by comparing kinematic data to a normative sample. The Gait Variability Index (GVI) is a related metric that quantifies the variability in spatio-temporal variables during gait. The GDI and GVI have been verified using marker-based motion capture approaches, but video-based markerless motion capture has not been compared using these tools in children with CP.

Frequency selective metasurface based radio frequency glucose sensor with a periodic array of meta cells.

Nowadays, the operating principle of most of the experimental electromagnetic glucose sensors is based on the effect of an anomalous dispersion caused by a direct contact between an object under test and a two-dimensional metasurface. Due to the repeated uses, the metasurface will be subjected to a chemical attack over time. To avoid this problem, this work proposes a novel glucose sensor that is equipped with an interfacial dielectric layer of 0.

Emerging drug delivery systems to alter tumor immunosuppressive microenvironment: Overcoming the challenges in immunotherapy for glioblastoma.

Glioblastoma (GBM) is a highly proliferative, lethal cancer of the brain. The median survival at eight months is ca. 6.

Raga Bhairavi in virtual reality reduces stress-related psychophysiological markers.

The effects of classical music on psychophysiological parameters are not well understood. This study aimed to investigate the impact of listening to raga Bhairavi, an Indian Classical Music for six days on anxiety, stress, depression, and heart rate variability (HRV) parameters. Forty-four individuals were randomly assigned to either the intervention group (VR-raga), where they listened to raga Bhairavi via 360° video in a virtual reality environment, or the control group, where there was no exposure to raga Bhairavi for six days.

ELISA-R: an R-based method for robust ELISA data analysis.

Enzyme-linked immunosorbent assay (ELISA) is a technique to detect the presence of an antigen or antibody in a sample. ELISA is a simple and cost-effective method that has been used for evaluating vaccine efficacy by detecting the presence of antibodies against viral/bacterial antigens and diagnosis of disease stages. Traditional ELISA data analysis utilizes a standard curve of known analyte, and the concentration of the unknown sample is determined by comparing its observed optical density against the standard curve.