Cycloplatam and oxoplatin--the new antitumor platinum compounds of the second generation.

Cycloplatam, ammine(cyclopentylamino)-S-(-)-malatoplatinum(II), and oxoplatin, cis-dichloro-diammine-trans-dihydroxoplatinum(IV), were first synthesized in the USSR. Their antitumor properties were found at the All-Union Cancer Research Center of the Academy of Medical Sciences of the USSR by the authors of this article. Both new drugs are less toxic than cisplatin and free from nephrotoxicity.

The antitumor activity of oxoplatinum.

A coordination complex cis-dichlorodiamminedihydroxoplatinum (IV) (oxoplatinum) was first synthesized in the USSR by Chugaev and Khlopin in 1927 [3]. Its marked antitumor properties were revealed by one of the authors of this article at the All-Union Cancer Research Center of the Academy of Medical Sciences of the USSR. The paper gives data on the antiblastic and side effects of oxoplatinum and also on the results of pharmacokinetic studies of the drug.

[Antitumor action of cis-dichlorodiammineplatinum(II) and the effectiveness of a combination with sarcolysine].

Therapeutic properties of cis-dichlorodiammineplatinum (II) were studied on 12 strains of transplantable tumors and leukemias in mice. The compound is characterized by a wide spectrum of antitumor action. The greatest effect was gained in adenocarcinoma of the lage intestine (strain AKATOL), proventricular cancer (strain PRG) and adenocarcinoma of the mammary gland (strain Ca-755).