Occupational safety assessment of biogenic urea nanofertilisers using pulmonary, and ocular models.

Nanomaterials (NMs) are now gaining popularity to be used in agriculture as fertilisers to reduce the dose of conventional fertilisers and enhance nutrient use efficiency. Urea has found its application as a conventional nitrogenous fertiliser since long, however, the nutrient use efficiency of the bulk form of urea is low due to issues related to ammonia volatilisation. This study proposes a biogenic synthesis route to develop urea nanoparticles that can be used as nano-fertiliser for better uptake and hence improved nutrient efficiency.

A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer's disease.

2-(piperazin-1-yl)N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamides are described as a new class of selective and potent acetylcholinesterase (AChE) inhibitors and amyloid β aggregation inhibitors. Formation of synthesized compounds (P1P9) was justified via H NMR, C NMR, mass spectra and single crystal X-Ray diffraction study. All compounds were evaluated for their acetylcholinesterase and butyrylcholinesterase inhibitory activity, inhibition of self-mediated Aβ aggregation and Cu(II)-mediated Aβ aggregation.