Targeting host inducible-heat shock protein 70 with PES-Cl is a promising antiviral strategy against SARS-CoV-2 infection and pathogenesis.

One of the fundamental mechanisms developed by the host to contain the highly infectious and rapidly proliferating SARS-coronavirus is elevation of body temperature, a natural fallout of which is heat shock proteins over-expression. Here, for the first time, we demonstrate that the SARS-CoV-2 exploits the host Heat shock protein 70 (Hsp70) chaperone for its entry and propagation, and blocking it can combat the infection. SARS-CoV-2 infection as well as febrile temperature enhanced Hsp70 expression in host Vero E6 cells.

Knowledge and Perception about Dental Implant and Its Complications among Dental and Medical Students-A Comparative Observational Survey.

Introduction: As dental implants become more widely used, there is a need to raise awareness about their potential complications. Professionals in the dental and medical fields must take responsibility for educating the public, and future professionals in these fields will play a key role in this effort.

Methodology: Dental and medical students were polled through online questionnaire, with questions posed in multiple-choice format, to gauge their knowledge of dental implants.

Efficacy of Cucurmin and Aloevera Extracts Gel as Local Drugs Delivery Agents.

Introduction: The usage of antimicrobials as local drug delivery (LDD) agents in the treatment of periodontitis has posed limitations due to the development of bacterial resistance, high cost, and unavailability, thus indicating the need for safer and economic alternatives.

Methodology: A split-mouth randomized clinical trial was carried out on 10 patients. Three sites in different quadrants were assigned, treatment modality of scaling and root planing (SRP) alone, SRP with LDD of curcumin gel, and SRP with LDD of 99% pure aloe vera gel, respectively.

Targeting Artemisinin-Resistant Malaria by Repurposing the Anti-Hepatitis C Virus Drug Alisporivir.

The emergence of Plasmodium falciparum resistance raises an urgent need to find new antimalarial drugs. Here, we report the rational repurposing of the anti-hepatitis C virus drug, alisporivir, a nonimmunosuppressive analog of cyclosporin A, against artemisinin-resistant strains of P. falciparum.

Graphene woven fabric-polydimethylsiloxane piezoresistive films for smart multi-stimuli responses.

The outstanding properties of graphene, including its electromechanical property, could be engineered for wearable electronic sensor platforms. The tubular graphene weaved into a mesh or graphene woven fabrics (GWF) has been reported as one of the most sensitive materials for deformation detection, as well as a promising temperature sensor. Herein, we present the performance of our developed flexible, stretchable, and multiple sensitive sensors fabricated from GWF embedded in polydimethylsiloxane (PDMS) film substrate.

Dependence of Precursor Graphite Flake Size on Nitrogen Doping in Graphene Oxide and Its Effect on OER Catalytic Activity.

We report the synthesis of nitrogen-doped graphene oxide, with 5.7-7.0 wt % nitrogen doping, from different sizes of precursor graphite and study its effect on the oxygen evolution reaction (OER) activity of IrO in an acidic medium.

Host SUMOylation Pathway Negatively Regulates Protective Immune Responses and Promotes Survival.

SUMOylation is one of the post-translational modifications that have recently been described as a key regulator of various cellular, nuclear, metabolic, and immunological processes. The process of SUMOylation involves the modification of one or more lysine residues of target proteins by conjugation of a ubiquitin-like, small polypeptide known as SUMO for their degradation, stability, transcriptional regulation, cellular localization, and transport. Herein, for the first time, we report the involvement of the host SUMOylation pathway in the process of infection of , a causative agent of visceral leishmaniasis.

electrochemical Raman investigation of charge storage in rGO and N-doped rGO.

In this study, in situ electrochemical Raman spectroscopy was applied to clarify the charge storage mechanism in three types of anodes, synthetic graphite, reduced graphene oxide (rGO), and nitrogen-doped reduced graphene oxide (N-rGO). The Li+ intercalation phenomenon was measured in LiPF6 electrolyte solution using a modified coin cell setup. The synthetic graphite anode showed the splitting of the G peak at the potential E < 0.

An all solid-state Li ion battery composed of low molecular weight crystalline electrolyte.

Conduction mechanisms in solid polymer electrolytes of Li ion batteries have always been a concern due to their theoretical limitation in conductivity value. In an attempt to increase the ionic conductivity of solid state electrolytes, used in lithium ion secondary batteries (LiBs), we studied the synthesis and conductive properties of a low molecular weight cyclic organoboron crystalline electrolyte. This electrolyte was expected to show better electrochemical properties than solid polymer electrolytes.

Evaluation of Alkylamine Modified Pt Nanoparticles as Oxygen Reduction Reaction Electrocatalyst for Fuel Cells via Electrochemical Impedance Spectroscopy.

Organically (octyl amine, OA) surface modified electrocatalyst (OA-Pt/CB) was studied for its oxygen reduction reaction (ORR) activity via dc methods and its charge and mass transfer properties were studied via electrochemical impedance spectroscopy (EIS). Comparison with a commercial catalyst (TEC10V30E) with similar Pt content was also carried out. In EIS, both the catalysts showed a single time-constant with an emerging high-frequency semicircle of very small diameter which was fitted using suitable equivalent circuits.

Few-Layered MoS/Acetylene Black Composite as an Efficient Anode Material for Lithium-Ion Batteries.

Novel MoS/acetylene black (AB) composite was developed using a single-step hydrothermal method. A systematic characterization revealed a few-layered, ultrathin MoS grown on the surface of AB. The inclusion of AB was found to increase the capacity of the composite and achieve discharging capacity of 1813 mAhg.

A crystalline low molecular weight cyclic organoboron compound for efficient solid state lithium ion transport.

We report the synthesis of a crystalline cyclic organoboron compound that shows an anomalous Li-ion conduction behaviour with specific composition and method of insertion of a Li salt. The enhanced ionic conductivity of crystalline boric ester/LiTFSI prepared by the grinding method should be due to the formation of regulated ion-conduction channels scaffolded by boron-anion interaction.

Boric ester-type molten salt via dehydrocoupling reaction.

Novel boric ester-type molten salt was prepared using 1-(2-hydroxyethyl)-3-methylimidazolium chloride as a key starting material. After an ion exchange reaction of 1-(2-hydroxyethyl)-3-methylimidazolium chloride with lithium (bis-(trifluoromethanesulfonyl) imide) (LiNTf2), the resulting 1-(2-hydroxyethyl)-3-methylimidazolium NTf2 was reacted with 9-borabicyclo[3.3.