Diverse roles of arrest defective 1 in cancer development.

Arrest defective 1 is an acetyltransferase that acetylates N-terminal amino acid or internal lysine residues of its target proteins. By acetylating its target proteins, ARD1 plays roles in many cellular activities, including proliferation, differentiation, autophagy, and apoptosis. In recent years, a number of investigations have emerged reporting the dysregulated expression of ARD1 in different types of cancer, including lung, liver, pancreas, breast, prostate, and colon cancer.

Environmentally sustainable route to SiO@Au-Ag nanocomposites for biomedical and catalytic applications.

A facile, sustainable, operationally simple and mild method for the synthesis of SiO@Au-Ag nanocomposites (NCs) using tuber extract is described and its catalytic, antibacterial and cytotoxic properties were investigated. The fabricated SiO@Au-Ag NCs were well characterized by UV-visible spectroscopy, transmission electron microscopy (TEM), energy-dispersive X-ray (EDX), Fourier transform infrared (FT-IR) spectroscopy, powder X-ray diffraction (XRD), thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS) to determine the optical activity, size and morphology, elemental composition, functional groups present, crystallinity, thermal stability and chemical state respectively. The obtained SiO@Au-Ag NCs exhibited spherical shape SiO decorated with Au and Ag nanoparticles.

Generation of protective immune response against anthrax by oral immunization with protective antigen plant-based vaccine.

In concern with frequent recurrence of anthrax in endemic areas and inadvertent use of its spores as biological weapon, the development of an effective anthrax vaccine suitable for both human and veterinary needs is highly desirable. A simple oral delivery through expression in plant system could offer promising alternative to the current methods that rely on injectable vaccines extracted from bacterial sources. In the present study, we have expressed protective antigen (PA) gene in Indian mustard by Agrobacterium-mediated transformation and in tobacco by plastid transformation.