Genetic determinants of chronic obstructive pulmonary disease in South Indian male smokers.

The development of chronic obstructive pulmonary disease, upon exposure to tobacco smoke, is the cumulative effect of defects in several genes. With the aim of understanding the genetic structure that is characteristic of our patient population, we selected forty two single nucleotide polymorphisms of twenty genes based on previous studies and genotyped a total of 382 samples, which included 236 patients and 146 controls using Sequenom MassARRAY system. Allele frequencies of rs2276109 (MMP12) and rs1800925 (IL13) differed significantly between patients and controls (p = 0.

Oxidative stress and antioxidant enzyme activity in South Indian male smokers with chronic obstructive pulmonary disease.

Background And Objective: Oxidative stress resulting from tobacco smoking has been suggested to play a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of the present study was to evaluate the oxidant and antioxidant levels in smokers with and without COPD.

Methods: Two hundred thirty-six patients with COPD and 150 smokers with no respiratory problems were selected.

Clinical presentation and predictors of outcome in patients with severe acute exacerbation of chronic obstructive pulmonary disease requiring admission to intensive care unit.

Background: Severe acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) is a common reason for emergency room (ER) visit about which little has been documented from India.

Methods: Prospective study of the clinical presentation and predictors of outcome in 116 patients presenting with severe AE-COPD requiring admission to the medical intensive care unit between January 2000 and December 2004.

Results: Their mean age was 62.