Publications by authors named "Prem Gathiram"
Introduction: The exact cause of preeclampsia (PE) remains elusive. Recently, many researchers have focused on the role of genetic variations in pathogenesis of PE. The renin-angiotensin-aldosterone system is affected in the pathogenesis of PE.
View Article and Find Full Text PDFWe investigated the effects of sildenafil citrate (SC) on podocyturia in N -nitro-L-arginine methyl ester hydrochloride (L-NAME) model of pre-eclampsia (PE). One hundred and twenty Sprague-Dawley rats (SDR) were divided into five groups like pregnant control (PC), early-onset PE (EOPE), late-onset PE(LOPE), early and late-onset PE with SC-treated groups [EOPE (SC); LOPE (SC)]. PE was induced in SDR by oral administration of L-NAME in drinking water for 4-8 days for EOPE and 8-14 day for LOPE.
View Article and Find Full Text PDFPre-eclampsia (PE), a hypertensive disorder of pregnancy, is detrimental to both mother and foetus. There is currently no effective treatment, but we have shown that Sildenafil Citrate (SC) improve various foetal outcomes in N-nitro-L arginine methyl ester (L-NAME) rat model of PE. Therefore, we aimed to investigate the effects of SC on a uterine angiogenic status and serum inflammatory markers in an L-NAME rat model of PE.
View Article and Find Full Text PDFBackground: Previous studies show a high prevalence of cardiovascular (CV) risk factors in South African (SA) Asian Indians, with the emergence of premature coronary artery disease in young Indian subjects.
Objective: To determine the prevalence of CV risk factors in this population.
Methods: This was a cross-sectional study of randomly selected adults aged 15 - 64 years from the suburb of Phoenix in Durban, KwaZulu-Natal Province, SA.
The optimization of a chronic nitric oxide synthase (NOS) inhibition model of pre-eclampsia by evaluating physiological changes.
Eur J Obstet Gynecol Reprod Biol
November 2014
Objectives: In order to address the gap in our understanding of the pathogenesis and pathophysiology of PE, we optimized the NOS inhibition animal model by comparing changes in different parameters at various time frames during pregnancy, in both early and late-onset PE.
Study Design: 120 nulliparous Sprague-Dawley rats were divided into 5 groups (n=24). A pregnant control, two groups that represented early and late-onset PE and two groups that were treated with sildenafil citrate (SC) to show reversal of the pre-eclamptic-like symptoms.
The year 2014 is an important year because it will mark the 25th Anniversary of the founding of the African Association of Physiological Sciences (AAPS) and initial talks to launch the International Society for Pathophysiology (ISP). Both these organizations had a foothold in Finland and both occurred during the IUPS Centennial Celebration Congress in 1989. The congress was hosted by the Finnish Physiological Society in Helsinki, Finland in July 1989.
View Article and Find Full Text PDFArticle Synopsis
- The study explores the unclear causes of pre-eclampsia (PE) in black South African women, focusing on angiogenic and vasoactive factors.
- Serum levels of sFlt-1 were found to be significantly higher and PlGF lower in early-onset PE, indicating a shift toward an anti-angiogenic state.
- Late-onset PE showed reduced placental VEGF mRNA and higher AT1 receptor expression, suggesting differing mechanisms in the development of early and late-onset PE.
Effects of a unique electromagnetic field system on the fertility of rats.
Arch Environ Occup Health
July 2009
Article Synopsis
- The study examined the effects of an electromagnetic field (EMFS-5) on the fertility of male and female rats by dividing them into groups with varying exposure.
- 32 breeding rats were either exposed to the EMFS for 8 hours a day over 10 days or sham exposed, followed by cohabitation for reproduction.
- Findings indicated that exposure did not significantly impact reproductive outcomes, such as litter size or the health of pups, leading to the conclusion that EMFS-5 does not affect rat fertility.
Sanguinarine is an alkaloid found in many medicinal plants. It has diverse biological activities, including modulation of nuclear factor-kappaB and of several enzymes. It is also known to induce apoptosis, perturb microtubules, and to have antimicrobial effects.
View Article and Find Full Text PDFSanguinarine downregulates AT1a gene expression in a hypertensive rat model.
J Cardiovasc Pharmacol
August 2006
We studied the in vivo effects of sanguinarine in a hypertensive rat model and its effects on AT1a mRNA expression in kidney tissues. Rats received daily for 14 d sanguinarine 0.1 mg/kg (SangL) and 0.
View Article and Find Full Text PDFUrinary heparan sulfate proteoglycan excretion in black African women with pre-eclampsia.
Acta Obstet Gynecol Scand
April 2002
Background: The heparan sulfate proteoglycan of the glomerular basement membrane is considered to be mainly responsible for the charge selectivity of the glomerular basement membrane. Decreased heparan sulfate proteoglycan results in a decreased anionic charge of the glomerular basement membrane with increased heparan sulfate proteoglycan in the urine, and is believed to be responsible for the proteinuria in pre-eclampsia.
Aim: To determine the urinary heparan and chondroitin sulfate proteoglycan levels in women with pre-eclampsia.