Publications by authors named "Prem A H Nichani"
Article Synopsis
- This study evaluated the performance of various large language model (LLM) chatbots, including ChatGPT and Google Bard, in responding to cornea-related medical scenarios to assess their effectiveness in clinical settings.
- ChatGPT performed the best overall, scoring an average of 83.8% across various evaluation criteria, while Google Bard excelled in readability metrics.
- The research underscores the potential benefits of LLMs in ophthalmology but emphasizes the need for careful monitoring and professional oversight to ensure safety and effectiveness in patient care.
Article Synopsis
- Intravitreal anti-VEGF therapy is a key treatment for retinal diseases, but the effectiveness and safety of new bispecific agents like faricimab compared to traditional monoclonal anti-VEGF agents is still uncertain.
- A systematic review of studies from 2015 to 2024 analyzed outcomes from 13 studies involving both faricimab and standard anti-VEGF therapy, focusing on visual acuity, central subfield thickness, and adverse events.
- Results showed no significant difference in visual acuity between the two treatments, but faricimab reduced central subfield thickness more effectively in cases of diabetic macular edema and retinal vein occlusion, with similar rates of ocular side effects across both agent types.
Objective: To obtain prescription eyewear in Ontario, eye exams must be performed by optometrists or ophthalmologists (eye care providers [ECPs]). In 2004, government-insured routine eye exams were delisted for Ontarians aged 20-64 leaving eye exam coverage only for those aged ≤19 and 65+. We assessed whether having eyewear insurance impacts Ontarians' utilization of ECPs.
View Article and Find Full Text PDFTo present a rare case of subfoveal choroidal neovascular membrane (CNVM) secondary to idiopathic intracranial hypertension. A case was evaluated. A 21-year-old woman presented with a 2-week history of painless blurred vision in the right eye.
View Article and Find Full Text PDFUnlabelled: [Box: see text] Background and Objective: This meta-analysis evaluates treat-and-extend regimens relative to monthly and as-needed (prn) regimens using anti-vascular endothelial growth factor agents for diabetic macular edema and macular edema secondary to retinal vein occlusion.
Materials And Methods: Comparative studies evaluating a treat-and-extend regimen relative to a monthly or prn regimen with anti-vascular endothelial growth factor therapy for diabetic macular edema or macular edema secondary to retinal vein occlusion were included following a systematic literature search.
Results: Seven studies of 984 eyes were included.
Intravitreal injections of antiangiogenic agents are pivotal in treating neovascular age-related macular degeneration (nAMD). The comparative efficacy and safety of treat-and-extend (T&E) versus bimonthly, monthly, and pro re nata (PRN) dosing remains unclear. A systematic review and meta-analysis of English-language RCTs reporting on efficacy and/or safety outcomes of dosing regimens of anti-VEGF agents in nAMD was performed.
View Article and Find Full Text PDFPurpose: Keratoconus (KCN), classically defined as a noninflammatory corneal ectasia, was recently associated with chronic inflammation. This study aimed to further evaluate the association between inflammation and KCN severity by assessing patient tear films.
Methods: Retrospective chart review of consecutive patients (July 2016-February 2020) referred to a tertiary KCN centre.
Purpose: The efficacy and safety of scleral buckling (SB) versus combination SB and pars plana vitrectomy (SB + PPV) for rhegmatogenous retinal detachment (RRD) repair remains unclear.
Methods: A systematic review and meta-analysis was conducted to identify comparative studies published from Jan 2000-Jun 2021 that reported on the efficacy and/or safety following SB and SB + PPV for RRD repair. Final best-corrected visual acuity (BCVA) represented the primary endpoint, while reattachment rates and ocular adverse events were secondary endpoints.
Topic: It is unclear whether there are differences in safety and efficacy between pars plana vitrectomy (PPV) alone and PPV with a supplemental scleral buckle (SB; PPV-SB) for the treatment of rhegmatogenous retinal detachment.
Clinical Relevance: This meta-analysis aimed to compare the safety and efficacy of these surgical procedures.
Methods: In this meta-analysis, Ovid MEDLINE, Embase, and Cochrane Library were systematically searched (January 2000-June 2021).
Pars plana vitrectomy (PPV) and scleral buckling (SB) are two of the most common surgical treatments for rhegmatogenous retinal detachment (RRD). This meta-analysis compares the efficacy and safety of PPV and SB for RRD. A systematic literature review was performed using Ovid MEDLINE, EMBASE and Cochrane CENTRAL from 2000 to June, 2021.
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