Publications by authors named "Preetish K Murthy"
Novel Porcine Model Reveals Two Distinct LGR5 Cell Types During Lung Development and Homeostasis.
Am J Respir Cell Mol Biol
November 2024
Article Synopsis
- Cells expressing LGR5 are crucial for homeostasis and regeneration in various organs, but their function in the human lung has not been well studied, especially compared to findings from mouse models.
- Utilizing a new transgenic pig model, researchers identified two significant populations of LGR5 cells in the lung that are similar to those found in humans but not in mice.
- The study reveals that LGR5 expression occurs transiently in fetal lung progenitor cells and is absent in postnatal lungs but can be reactivated in specific organoid models, highlighting the complex roles of LGR5 cells in lung development and potential for repair.
Emerging evidence suggests that microRNAs can initiate asymmetric division, but whether microRNA and protein cell fate determinants coordinate with each other remains unclear. Here, we show that miR-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent feedforward loop (IFFL) targeting Notch to separate stem and non-stem cell fates robustly. Perturbation of the IFFL leads to a new intermediate cell population with plastic and ambiguous identity.
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