Publications by authors named "Preeti Rajendren"
Background: Schizophrenia, a chronic severe psychiatric illness of unknown aetiology, has been shown to be associated with HLA alleles but at varied degree in different population. The present study has focussed on analysing the frequency of HLA class I and class II alleles in persons with schizophrenia from South India.
Methods: Ninety seven individuals with schizophrenia and 103 age- and gender-matched controls were typed for HLA- A, B, C, DRB1 and DQB1 loci by next-generation sequencing in Illumina MiniSeq using MIA FORA NGS FLEX HLA typing kit.
Article Synopsis
- A genome-wide association study (GWAS) in an Indian population identified novel genetic loci associated with schizophrenia, contributing to the understanding of the disorder beyond findings from European populations.
- The study involved 3,092 participants, including individuals with schizophrenia, their family members, and unrelated controls, using rigorous diagnostic criteria and recruitment methods from various medical facilities in Chennai.
- A significant association was found with a specific locus on chromosome 8q24.3, showing a potential risk allele that declined in frequency, suggesting natural selection influences on its prevalence in the Indian population.