Effects of (-)-MBP, a novel 5-HT agonist and 5-HT antagonist/inverse agonist on brain activity: A phMRI study on awake mice.

A novel serotonin ligand (-)-MBP was developed for the treatment of schizophrenia that has 5-HT antagonist activity together with 5-HT agonist activity. The multi-functional activity of this novel drug candidate was characterized using pharmacological magnetic resonance imaging. It was hypothesized (-)-MBP would affect activity in brain areas associated with sensory perception.