Comprehensive analysis of Apigetrin's effects on liver cancer cells: Insights from bioinformatics, in vitro studies, and next-generation transcriptome sequencing.

Despite numerous attempts to understand the molecular mechanisms behind the development of liver cancer, it continues to pose a significant worldwide health challenge. Transcriptome sequencing, a powerful tool in molecular biology, has played a pivotal role in uncovering the intricate gene expression profiles underlying hepatocellular carcinoma (HCC). In the present study, we identified a total of 808 differentially expressed genes (DEGs), with 584 exhibiting downregulation, and 224 showing upregulation following apigetrin treatment.

Small chemical molecules regulating the phytohormone signalling alter the plant's physiological processes to improve stress adaptation, growth and productivity.

Small chemical molecules are attractive agents for improving the plant processes associated with plant growth and stress tolerance. Recent advances in chemical biology and structure-assisted drug discovery approaches have opened up new avenues in plant biology to discover new drug-like molecules to improve plant processes for sustained food production. Several compounds targeting phytohormone biosynthesis or signalling cascades were designed to alter plant physiological mechanisms.

Synthesis, characterization, DFT studies and evaluation of the potential anti-tumour activity of nicotinic hydrazide based Schiff base using in vitro and molecular docking techniques.

Breast cancer, one of the most serious issues worldwide, has been raising day by day. It has now become a necessary to develop a suitable drug to combat this terrible illness. Schiff bases are increasingly being used as powerful medications for a number of illnesses.

Identification of Potential Inhibitors Targeting GTPase-Kirsten RAt Sarcoma Virus (K-Ras) Driven Cancers via E-Pharmacophore-Based Virtual Screening and Drug Repurposing Approach.

Background: Mutations in the gene are among the most frequent genetic alterations in various cancers, and inhibiting RAS signaling has shown promising results in treating solid tumors. However, finding effective drugs that can bind to the RAS protein remains challenging. This drove us to explore new compounds that could inhibit tumor growth, particularly in cancers that harbor K-Ras mutations.

Exploration of the performance of iron-based superhydrophilic meshes for oil-water separation.

This study investigates the oil-water separation capability of iron-based superhydrophilic meshes. It also intends to provide an optimistic view of their potential for industrial application. Oil-water separation performance of the 150 mesh, 300 mesh, and 400 mesh is primarily examined by analyzing the efficiency and speediness of separation as well as the limit of oil intrusion using petroleum based oils.

Heterostructured γ-FeO/FeTiO magnetic nanocomposite: An efficient visible-light-driven photocatalyst for the degradation of organic dye.

The catalyst recovery is the major concern in commercialization of photocatalysts for the industrial effluent treatment process. To overcome this major issue, FeO based magnetic photocatalytic heterostructure ɣ-FeO/FeTiO nanocomposite was synthesized by hydrothermal method. FeO is the cheapest visible active magnetic photocatalytic material, but it has the limitation of fast e/h + recombination.

Mutations in G6PC2 gene with increased risk for development of type 2 diabetes: Understanding via computational approach.

An increase in the fast blood glucose (FBG) levels has been linked to an increased risk of developing a chronic condition, type 2 diabetes (T2D). The mutation in the G6PC2 gene was identified to have a lead role in the modulation of FBG levels. The abnormal regulation of this enzyme influences glucose-stimulated insulin secretion (GSIS), which controls the insulin levels corresponding to the system's glucose level.

Corneal perforation following arcuate keratotomy in femtosecond laser assisted cataract surgery-a case series.

Purpose: Identification and management of corneal perforation during arcuate keratotomy in femtosecond laser assisted cataract cases (FLACS).

Observation: Low astigmatism correction in patients undergoing FLACS can be done by arcuate keratotomy incision made by femto-laser. Corneal perforation following arcuate keratotomy is commonly noted with manual incision but very few cases have been reported with femtolaser arcuate keratotomy (FSAK).

A Comparative Study of Salivary Flow Rate, pH, Buffer Capacity, Total Antioxidant Capacity, and Ferritin Levels in Children with Beta Thalassemia Major and Healthy Children.

Introduction: Thalassemia is a genetically diverse group of disease which occurs due to an imbalance in the production of the alpha and beta chains with ensuring chronic hemolysis, ineffective erythropoiesis, and iron overload.

Aim And Objective: The main aim of the study is to compare the salivary flow rate, pH, buffer capacity, total antioxidant capacity, and ferritin levels in children with beta thalassemia major and healthy children.

Materials And Methods: The present study includes 40 children consisting of 20 beta thalassemia major and 20 healthy children.

Assessment of Anti-Inflammatory and Antioxidant Effects of Peel (CUP) Flavonoids on LPS-Stimulated RAW 264.7 Cells.

is a popular medicinal herb in several Asian countries, in particular South Korea. peel (CUP) has several biologically active compounds, including flavonoids. Hence, this research aimed to label the flavonoids from CUP by HPLC-MS/MS analysis and examine their anti-inflammatory and antioxidant potential on LPS-stimulated RAW 264.

Excellent photocatalytic performances of CoO-AC nanocomposites for H production via wastewater splitting.

Natural sunlight-driven photocatalytic hydrogen production from wastewater is one of the most desirable techniques that can realize future green energy technology. Herein, we report the synthesis and the characterization of the biomass activated carbon (AC)-decorated cobalt oxide (CoO) nanocomposites for solar-stimulated photocatalytic hydrogen production from sulphide wastewater. The CoO-AC nanocomposites were ultrasonically synthesized by using hydrothermally-grown spinel CoO nanoflakes and biomass-derived AC nanoflakes.

Synthesis of tri-metallic surface engineered nanobiochar from cynodon dactylon residues in a single step - Batch and column studies for the removal of copper and lead ions.

Superparamagnetic nanocomposites integrated with multiple metals, and surface engineered nanoparticles play a vital role in the removal of heavy metals. In the present study, amino-functional silica-coated magnetic nanocomposites with biochar synthesised from Cynodon dactylon plant residues are prepared in a single step reaction process. The synthesised nanocomposites are characterized using various analytical techniques such as FTIR to determine their functional entities, SEM, TEM, EDX and VSM to analyse the size (~50 nm), elements and magnetic nature of the nanocomposites.

Profile of complications in pterygium surgery - A retrospective analysis.

Purpose: Analysis of complication profile after pterygium excision, in primary and recurrent pterygia.

Methods: Retrospective analysis of all the patients who had undergone pterygium excision in a tertiary center in South India from 2010 to 2018 was analyzed. A total of 2356 eyes in 2028 patients were included in the study.

Utilizing 2D materials to enhance H generation efficiency via photocatalytic reforming industrial and solid waste.

Sustainable valorization of industrial and solid wastes by utilizing them as feedstock to generate H via the photocatalytic reforming (PR) process holds great promise. It can also be an effective method to treat solid waste that otherwise would require tedious and expensive processes. This approach has the potential to offer energy solutions and form value-added chemicals.

Gram-scale synthesis of ZnS/NiO core-shell hierarchical nanostructures and their enhanced H production in crude glycerol and sulphide wastewater.

Design and development of the efficient and durable photocatalyst that generates H fuel utilizing industrial wastewater under solar light irradiation is a sustainable process. Innumerable photocatalysts have been reported for efficient H production, but their large-scale production with the same efficiency of H production is a challenging task. In this study, a few gram-scale syntheses of ZnS wrapped with NiO hierarchical core-shell nanostructure via the surfactant-mediated process has been reported.

Efficacy of second donor conjunctival graft from the same site for pterygium - A retrospective analysis.

Purpose: To know the efficacy of the second donor conjunctival graft from the same site as that of the previous donor area in pterygium treatment.

Methods: Case record of patients were retrospectively analysed and those patients who had undergone pterygium excision previously, either for nasal or temporal pterygium excision and came with complaints of pterygium growth in opposite side of the bulbar conjunctiva in the same eye were included in the study. The patients with double head pterygium previously treated only over one side were also included.

Study of change in contrast sensitivity in relation to depth of ablation after wavefront optimized myopic laser-assisted keratomileusis.

Purpose: The aim of this work was to study the change in contrast sensitivity (CS) in relation to depth of stromal ablation after wavefront-optimized (WFO) myopic laser in situ keratomileusis (LASIK).

Methods: This was as prospective, longitudinal, comparative study. The study participants were divided into two groups: Group 1 ≤50 μ ablation depth; 60 eyes and group 2 >50 μ ablation depth; 60 eyes.

Carbonyl Cytotoxicity Affects Plant Cellular Processes and Detoxifying Enzymes Scavenge These Compounds to Improve Stress Tolerance.

Oxidative stress is ubiquitous in environmental stresses and prevails over the cellular metabolic and phenotypic responses in plants. Reactive oxygen species (ROS) generated under stress affect macromolecules to form another group of toxic compounds called reactive carbonyl compounds (RCCs). These molecules have a longer half-life than ROS and cause carbonyl stress that affects cellular metabolism, cellular homeostasis, and crop productivity.

Optimization of operating parameters for gas-phase photocatalytic splitting of H2S by novel vermiculate packed tubular reactor.

Hydrogen production by gas-phase photocatalytic splitting of Hydrogen Sulphide (H2S) was investigated on four semiconductor photocatalysts including CuGa1.6Fe0.4O2, ZnFe2O3, (CdS + ZnS)/Fe2O3 and Ce/TiO2.

Determinants of ventilator associated pneumonia and its impact on prognosis: A tertiary care experience.

Background: Ventilator associated pneumonia (VAP) is a major cause of poor outcome among patients in the intensive care units (ICU) world-wide. We sought to determine the factors associated with development of VAP and its prognosis among patients admitted to different ICUs of a Tertiary Care Hospital in India.

Methodology: We did a matched case control study during October 2009 to May 2011 among patients, ≥18 years with mechanical ventilation.

Third-generation cephalosporin-resistant Vibrio cholerae, India.

Vibrio cholerae resistance to third-generation cephalosporins is rarely reported. We detected a strain that was negative for extended-spectrum β-lactamase and positive for the AmpC disk test, modified Hodge test, and EDTA disk synergy test and harbored the blaDHA-1 and blaNDM-1 genes. The antimicrobial drug susceptibility profile of V.

Trichomoniasis: An update.

Trichomoniasis is one of the most common sexually transmitted infections (STIs) with a prevalence of 5-75%. In India, trichomoniasis accounts for 2-7% of all STIs. Infection with Trichomonas vaginalis is known to cause vaginitis.