Publications by authors named "Preethi Mayura Guru"
The blood stage of the plasmodium parasite life cycle is responsible for the clinical symptoms of malaria. Epidemiological studies have identified coincidental malarial endemicity and multiple red blood cell (RBC) disorders. Many RBC disorders result from mutations in genes encoding cytoskeletal proteins and these are associated with increased protection against malarial infections.
View Article and Find Full Text PDFBackground: Combination immunotherapies can be effective against subcutaneous tumors in mice but the effect against orthotopic malignant disease is less well characterized. In particular, a combination of three agonist antibodies, termed Tri-mAb, consisting of anti-DR5, anti-CD40 and anti-CD137 has previously been demonstrated to eradicate a large proportion of subcutaneous renal cell carcinoma (Renca) tumors (75% long-term survival), but the effect against orthotopic disease is not known.
Purpose: To determine the relative response of orthotopic tumors, we inoculated Renca into the kidney followed by treatment with Tri-mAb.
The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum.
J Immunother
April 2009
Article Synopsis
- The Lewis-Y carbohydrate antigen is present on various tumors, with expression rates ranging significantly in different cancer types.
- Genetic modification of T cells to target Lewis-Y led to effective anti-tumor responses without being hindered by soluble Lewis-Y in patient serum.
- These findings support the potential of Lewis-Y as a target for immunotherapy using genetically redirected T cells.