Publications by authors named "Preet Joshi"
Article Synopsis
- Previous research highlights the role of IL-17A in regulating gut microbiota and overall metabolic functions, but the specific site of IL-17RA signaling has not been explored.
- Using specific mouse models that lack IL-17RA in either the intestines or liver, the study found that gut IL-17RA signaling is crucial for managing metabolic functions when exposed to a high-fat diet.
- Mice lacking intestinal IL-17RA exhibited negative effects like poor glucose metabolism, abnormal hormone levels, increased body fat, and greater liver fat accumulation, linking changes in gut microbiota to systemic glucose regulation.
Mucosal Immunol
March 2021
Article Synopsis
- IL-22 signaling plays a vital role in protecting the intestines, yet identifying the specific cell types that respond to it has been challenging due to the receptor’s expression across various cells.
- Research indicates that IL-22 signaling is linked with the differentiation of Paneth cells, important components of intestinal defense, rather than intestinal stem cells.
- The study reveals that IL-22 functions within Paneth cells to enhance their maturation, antimicrobial abilities, and interaction with gut microbiota, crucial for fighting off pathogens like Salmonella.
