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Publications by authors named "Preenapan Changphasuk"

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SRPK Inhibitors Reduce the Phosphorylation and Translocation of SR Protein Splicing Factors, thereby Correcting , and Splicing Errors and Enabling Apoptosis of Cholangiocarcinoma Cells.
Preenapan Changphasuk Chaturong Inpad Sukanya Horpaopan Sasiprapa Khunchai Suchada Phimsen

Front Biosci (Schol Ed)

September 2024

Article Synopsis
  • Cholangiocarcinoma (CCA) is a bile duct cancer prevalent in Thailand, characterized by poor prognosis and low survival rates due to challenges in early detection and treatment.
  • The study explores the role of serine/arginine protein kinases (SRPKs) in CCA, specifically how their hyperphosphorylation affects splicing factors linked to cancer-related mRNA errors.
  • Results indicate that high levels of SRPK1 correlate with shorter patient survival and that SRPK inhibitors increase cell death in CCA cell lines, revealing potential targets for new treatments.
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