Publications by authors named "Predrag Stojadinovic"

Introduction: Atrial fibrillation (AF) can cause or aggravate heart failure (HF). Catheter ablation (CA) is an effective treatment for AF. This study focused on the feasibility and outcomes of emergent AF ablation performed during hospitalization for acute HF.

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Aims: Catheter ablation is an effective treatment method for recurrent ventricular tachycardias (VTs). However, at least in part, procedural and clinical outcomes are limited by challenges in generating an adequate lesion size in the ventricular myocardium. We investigated procedural and clinical outcomes of VT ablation using a novel 'large-footprint' catheter that allows the creation of larger lesions either by radiofrequency (RF) or by pulsed field (PF) energy.

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Article Synopsis
  • Pulsed electric field (PEF) energy shows potential as an effective method for catheter ablation in atrial fibrillation (AF), but its impact on red blood cells (erythrocytes) is not well understood.
  • A study involving 60 AF patients found that PEF ablation significantly increased levels of free hemoglobin, lactate dehydrogenase, and bilirubin, indicating intravascular hemolysis after the procedure.
  • The results suggested that the extent of hemolysis correlates strongly with the number of PEF applications, with more than 74 applications being linked to significant damage to red blood cells.
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Catheter ablation (CA) has become an established treatment strategy for managing recurrent ventricular tachycardias (VTs) in patients with structural heart disease. In recent years, percutaneous mechanical circulatory support (PMCS) devices have been increasingly used intra-operatively to improve the ablation outcome. One indication would be rescue therapy for patients who develop haemodynamic deterioration during the ablation.

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Article Synopsis
  • A prospective observational study evaluated the use of pulsed electric field (PF) ablation for treating ventricular arrhythmias, focusing on its efficacy and safety in a small patient population of 44 individuals.
  • The study showed an 84% acute success rate in eliminating frequent ventricular premature complexes (VPCs) and non-inducibility of ventricular tachycardia (VT), indicating that PF ablation can effectively treat these conditions.
  • At a 3-month follow-up, 81% of patients with VPCs experienced sustained suppression, but only 52% of patients with scar-related VT remained free of any arrhythmias, suggesting that while PF ablation is promising, its long-term effectiveness for VT may need further
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Aims: Patients with structural heart disease (SHD) undergoing catheter ablation (CA) for ventricular tachycardia (VT) are at considerable risk of periprocedural complications, including acute haemodynamic decompensation (AHD). The PAINESD score was proposed to predict the risk of AHD. The goal of this study was to validate the PAINESD score using the retrospective analysis of data from a large-volume heart centre.

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Plasma natriuretic peptides (NPs) are increased in patients with atrial fibrillation (AF) compared with the patients with sinus rhythm. This study investigated whether this phenomenon is intrinsic to heart rhythm irregularity and independent of the heart rate and left atrial pressure (LAP) overload. We investigated 46 patients (age: 59 ± 10 years, male gender: 77%) with non-valvular paroxysmal AF who were scheduled for catheter ablation and had documented stable sinus rhythm for at least 18 hours before the procedure.

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Introduction: Atrial fibrillation (AF) is the most common sustained arrhythmia in humans. The onset of the arrhythmia can significantly impair cardiac function. This hemodynamic deterioration has been explained by several mechanisms such as the loss of atrial contraction, shortening of ventricular filling, or heart rhythm irregularity.

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Background: Pulmonary vein isolation (PVI) by radiofrequency (RF) energy is associated with a collateral ganglionated plexi ablation. Pulsed electric field (PEF) is a nonthermal energy source that preferentially affects the myocardial cells and spares neural tissue.

Objectives: This study investigated whether PVI by a PEF compared with RF energy will result in less prominent alteration of the cardiac autonomic nervous system.

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Aim: To describe clinical characteristics, procedural details, specific challenges, and outcomes in patients with HeartMate3™ (HM3), a left ventricular assist device system with a magnetically levitated pump, undergoing ventricular tachycardia ablation (VTA).

Methods And Results: Data were collected from patients with an HM3 system who underwent VTA in seven tertiary centres. Data included baseline patient characteristics, procedural data, mortality, and arrhythmia-free survival.

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Aims: Catheter ablation (CA) for atrial fibrillation (AF) has a considerable risk of procedural complications. Major vascular complications (MVCs) appear to be the most frequent. This study investigated gender differences in MVCs in patients undergoing CA for AF in a high-volume tertiary center.

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