Publications by authors named "Precious Earldom Mulaudzi"
Background: Embryoid bodies (EBs) are three-dimensional (3D) multicellular cell aggregates that are derived from stem cell and play a pivotal role in regenerative medicine. They recapitulate many crucial aspects of the early stages of embryonic development and is the first step in the generation of various types of stem cells, including neuronal stem cells. Current methodologies for differentiating stem cells into neural embryoid bodies (NEBs) in vitro have advanced significantly, but they still have limitations which necessitate improvement.
View Article and Find Full Text PDFRegenerative medicine has developed as a promising discipline that utilizes stem cells to address limitations in traditional therapies, using innovative techniques to restore and repair damaged organs and tissues. One such technique is the generation of three-dimensional (3D) organoids in stem cell therapy. Organoids are 3D constructs that resemble specific organs' structural and functional characteristics and are generated from stem cells or tissue-specific progenitor cells.
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- - Tomato curly stunt virus (ToCSV) affects tomatoes in South Africa and is similar to the tomato yellow leaf curl virus, but mechanisms of resistance in tomatoes infected with ToCSV are not well understood.
- - The study aimed to compare the global methylation profiles of ToCSV in two tomato lines: a tolerant line (NIL396) and a susceptible line (NIL395), finding greater methylation in the tolerant plants.
- - Results indicated significant differences in methylation patterns and expressed genes related to methylation in T versus S plants, particularly in specific genomic regions, highlighting the need for further research to understand the connections to resistance.