Computational Investigation of the Therapeutic Potential of in the Management of Erectile Dysfunction.

Erectile dysfunction (ED) is a multifactorial social problem affecting men worldwide. While phosphodiesterase type 5 inhibitors (PDE5) like sildenafil are commonly used, they often present side effects, underscoring the need for alternative therapies. Therefore, this study investigated the potential of phytochemicals from in the management of ED.

Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits.

There is a renewed interest on the reliance of food-based bioactive compounds as sources of nutritive factors and health-beneficial chemical compounds. Among these food components, several proteins from foods have been shown to promote health and wellness as seen in proteins such as α/γ-conglutins from the seeds of species (Lupin) a genus of leguminous plant that are widely used in traditional medicine for treating chronic diseases. Lupin-derived peptides (LDPs) are increasingly being explored and they have been shown to possess multifunctional health improving properties.

leaf extract modulates hyperglycaemia, inhibits redox imbalance and inflammation in alloxan-induced diabetic nephropathy.

Background: leaf is used traditionally to treat diabetes and other diseases. The present study aimed to provide the modulatory effect of on hyperglycemia, inhibitory effect of redox imbalance and inflammation in alloxan-induced nephropathy in Wistar rats.

Methods: Alloxan monohydrate was used to induce diabetes by an intraperitoneal injection of (150 mg/kg).

Gongronema latifolium Benth. leaf extract attenuates diabetes-induced neuropathy via inhibition of cognitive, oxidative stress and inflammatory response.

Background: Gongronema latifolium (G. latifolium) Benth. leaves are traditionally used to treat diabetes mellitus (DM) and other diseases in Nigeria and West Africa.

Cnidoscolus aconitifolius (Mill.) I. M. Johnst leaf extract prevents oxidative hepatic injury and improves muscle glucose uptake ex vivo.

Total phenol, total flavonoid, and ameliorative potentials of aqueous leaf extract of Cnidoscolus aconitifolius in Fe -induced oxidative stress in hepatic tissue and muscle glucose uptake using ex vivo models were assessed. These were carried out using standard procedures. The results revealed that the extract showed the presence of total phenol and total flavonoid, as well as free radicals scavenging abilities in a dose-dependent manner.

Antihyperglycaemia and related gene expressions of aqueous extract of leaf in alloxan-induced diabetic rats.

Benth (Asclepiadaceae) has been highly utilized in controlling diabetes mellitus traditionally in the eastern part of Nigeria. Antihyperglycaemic and related gene expressions of aqueous extract of leaf in alloxan-induced diabetic rats. Forty-eight female Wistar rats were induced intraperitoneally using alloxan (150 mg/kg body weight).