prevents the detrimental effects of cyclophosphamide on ovarian function in Wistar rats: An experimental study.

Background: Cyclophosphamide (CP) is an anticancer agent, but its chronic administration induces ovarian toxicity.

Objective: We evaluated the effects of aqueous extract (AE) and methanol extract (ME) of ( ) on CP-induced ovarian toxicity in rats.

Materials And Methods: 40 female Wistar rats (10 wk, 170-200 gr) were distributed into 8 groups (n = 5/each) as follows: 1) healthy control; 2) CP+distilled water (10 ml/kg/d); 3) CP+3%-tween 80 (10 mL/kg/d); 4) CP+clomiphene citrate (2 mg/kg/d); 5, 6) CP+AE of (55 and 110 mg/kg/d); and 7, 8) CP+ME of (55 and 110 mg/kg/d).