Synthesis and Biological Screening of New 2-(5-Aryl-1-phenyl-1-pyrazol-3-yl)-4-aryl Thiazole Derivatives as Potential Antimicrobial Agents.

A new series of 2-(5-aryl-1-phenyl-1-pyrazol-3-yl)-4-aryl thiazoles (-) have been synthesized by a cyclocondensation reaction of 5-aryl-1-phenyl-1-pyrazole-3-carbothioamide (-) with substituted phenacyl bromide (-). The structure of newly synthesized 2-(5-aryl-1-phenyl-1-pyrazol-3-yl)-4-aryl thiazole (-) derivatives was characterized by spectroscopic analysis. The compounds - were evaluated for antibacterial activity against (NCIM 2574), (NCIM 2388), (NCIM 2063), (NCIM 2178), and antifungal activity against (ATCC 504) and (NCIM 3100).