Publications by authors named "Pravesh Regmi"
Article Synopsis
- Research on COVID-19 vaccination in immune-deficient people largely centers on cancer and organ transplant recipients, showing that 88% developed antispike IgG after the second vaccine dose, increasing to 93% by six months post-third dose.
- However, the antibody levels in immune-deficient patients were significantly lower than those in healthy volunteers, never exceeding one-third of their levels.
- The study suggests that while three doses of the vaccine generate an antibody response, additional doses may be necessary for improved protection, especially against the Omicron BA.1 variant, warranting further investigation into the effectiveness of booster shots.
Our previous study showed that cells from medically important arthropods, such as ticks, secrete extracellular vesicles (EVs) including exosomes that mediate transmission of flavivirus RNA and proteins to the human cells. Understanding the molecular determinants and mechanism(s) of arthropod-borne flavivirus transmission via exosome biogenesis is very important. In this current study, we showed that in the presence of tick-borne Langat Virus (LGTV; a member of tick-borne encephalitis virus complex), the expression of arthropod SMase, a sphingomyelinase D (SMase D) that catalyzes the hydrolytic cleavage of substrates like sphingomyelin (SM) lipids, was significantly reduced in both ticks () and in tick cells ().
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