Publications by authors named "Praveena Idaikkadar"
Purpose Of Review: In this review article we describe the cardiovascular adverse events associated with BRAF and MEK inhibitors as well as their pathophysiologic mechanisms and provide up to date guidance for risk stratified surveillance of patients on treatment and the optimal management of emergent cardiotoxicities.
Recent Findings: Combination BRAF/MEK inhibition has become an established standard treatment option for patients with a wide variety of BRAF mutant haematological and solid organ cancers, its use is most commonly associated with stage three and metastatic melanoma. The introduction of these targeted drugs has significantly improved the prognosis of previously treatment resistant cancers.
Article Synopsis
- Cardiotoxicity, a significant side effect of tyrosine-kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs), is often under-reported and can affect patients with non-small-cell lung cancer (NSCLC).
- A study at The Royal Marsden Hospital analyzed 451 patients, finding that 19.5% developed cardiotoxicity, particularly among those with prior diabetes, a history of smoking, or existing cardiovascular disease.
- Results suggest that these risk factors could interact, increasing the likelihood of cardiotoxicity, highlighting the need for better risk stratification to enhance patient care in the context of cancer treatment.
Background: Malignant bowel obstruction is a common cause of morbidity and mortality in patients with advanced ovarian cancer. Many patients aren't suitable for, or decline, surgical decompression. The outcomes for this frail group of patients are not well characterized.
View Article and Find Full Text PDFHOX genes are highly conserved members of the homeobox superfamily that have a crucial role in determining cellular identity. High grade ovarian cancer is the most lethal gynaecological malignancy. Our understanding of the role of HOX genes in the oncogenesis of ovarian cancer is evolving, and here we review their dysregulated expression patterns, their function in cell survival and invasion, their potential uses as biomarkers, and ways in which HOX genes are being targeted with new and existing drugs.
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