Characterizing the West Nile Virus's polyprotein from nucleotide sequence to protein structure - Computational tools.

Objectives: West Nile virus (WNV) belongs to the Flaviviridae family and causes West Nile fever. The mechanism of transmission involves the culex mosquito species. Infected individuals are primarily asymptomatic, and few exhibit common symptoms.

Exploring Phytoconstituents: Integrated Strategies of Network Pharmacology, Molecular Docking, Dynamic Simulations, and MMGBSA Analysis for Cancer Therapeutic Targets Discovery.

belongs to the Rosaceae family and has numerous therapeutic applications as potent plant-based medicine. Forty phytoconstituents (PCs) from the root and stem through n-hexane (NR and NS) and methanolic (MR and MS) extracts were identified in earlier studies. However, the PCs affecting human genes and their roles in the body have not previously been disclosed.

Anti-oncogenic Potential and Inflammation Modulatory Response of Green Synthesized Biocompatible Silver Nanoparticles.

This study presents a novel approach to synthesizing silver nanoparticles (Ag NPs) using a solution combustion synthesis (SCS) method with Catharanthus roseus (C. roseus) leaf extract. The NPs were thoroughly characterized through X-ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive X-ray (EDX), Transmission electron microscopy (TEM), and Selected area electron diffraction (SAED), elucidating their crystal structure.

Ectopic Lingual Thyroid-A Rare Presentation.

Lingual thyroid is a rare clinical entity due to failure of the embryonic gland to descend to its normal pretracheal location. We report a case of 29 years old male patient who presented with the complaints of difficulty in swallowing and phonation. The clinical and radiology features were diagnostic of ectopic lingual thyroid.

Tear biomarkers in dry eye disease: Progress in the last decade.

Dry eye disease (DED) is a commonly occurring, multifactorial disease characterized by reduced tear film stability and hyperosmolarity at the ocular surface, leading to discomfort and visual compromise. DED is driven by chronic inflammation and its pathogenesis involves multiple ocular surface structures such as the cornea, conjunctiva, lacrimal glands, and meibomian glands. The tear film secretion and its composition are regulated by the ocular surface in orchestration with the environment and bodily cues.

Tinnitus Prevalence and Associated Factors among Dental Clinicians in the United Arab Emirates.

Dental clinicians are at increased risk for developing tinnitus due to exposure to high levels of occupational noise. This study aimed to determine tinnitus prevalence and associated factors among dental clinicians. Interviews were conducted with 150 randomly selected dental clinicians using a questionnaire.

Management of bronchomalacia in infants post-cardiac surgery using synchronized nasal DuoPAP: A novel technology.

Background: Tracheo-bronchomalacia (TBM) is the weakness in the structural integrity of the cartilaginous ring and arch. It may occur in isolation with prematurity or secondarily in association with various congenital anomalies. Bronchomalacia is more commonly associated with congenital heart diseases.

Comparative analysis of flexural strength of abraded and polished porcelain surfaces - an in vitro study.

Typically, prosthodontists adjust ceramic restorations glazed surface by grinding prior to insertion. Such alterations of surfaces are necessary for the correction of occlusal interferences. We aimed to evaluate and compare the change in flexural strength of ceramic surfaces after re-glazing and polishing.

Metabolite profiling of (L.) H. Rob. and its herbal formulation by tandem mass spectroscopic analysis.

is a medicinal plant commonly known as little ironweed is used in various traditional systems of medicines. In , it is known as and is used as remedy for many ailments. It has been reported to possess numerous biological properties including diaphoretic, anthelmintic, diuretic, lithontriptic, anti-inflammatory and anticancer activities.

Anaemia in patients with type 2 diabetes mellitus without nephropathy is related to iron deficiency.

Background And Aims: Iron deficiency anaemia, although well reported in diabetic nephropathy, has not been well studied in type 2 diabetes patients in the absence of nephropathy. We studied the prevalence of anaemia and iron deficiency in type 2 diabetes patients without nephropathy.

Material And Methods: A total of 89 patients were selected for this study.

Poly (alanine)/NaOH/ MoS/MWCNTs modified carbon paste electrode for simultaneous detection of dopamine, ascorbic acid, serotonin and guanine.

The detection of biomolecules such as dopamine (DA), ascorbic acid (AA), serotonin (5-HT), and guanine (GU) is essential for biomedical chemistry and disease diagnosis. In this work, MoS/acid-treated MWCNTs composite (Ms-atCNTs) was first prepared and then used to modify carbon paste electrode (CPE), followed by electropolymerization of alanine in the presence of NaOH. The resulting modified electrode (p-Aln/Ms-atCNTCPE) was tested for the simultaneous detection of DA, AA, 5-HT, and GU using cyclic voltammetry and differential pulse voltammetry in phosphate buffer solution (PBS).

Molecular mapping of QTLs for yield related traits in recombinant inbred line (RIL) population derived from the popular rice hybrid KRH-2 and their validation through SNP genotyping.

The study was undertaken to identify the quantitative trait loci (QTLs) governing yield and its related traits using a recombinant inbred line (RIL) population derived from the popular rice hybrid, KRH-2 (IR58025A/KMR3R). A genetic map spanning 294.2 cM was constructed with 126 simple sequence repeats (SSR) loci uniformly distributed across the rice genome.

Intraoperative performance and long-term postoperative outcomes after scleral fixation of IOLs with polytetrafluoroethylene suture.

Purpose: To report intraoperative performance and long-term postoperative outcomes after scleral fixation of intraocular lenses (IOLs) with polytetrafluoroethylene suture (PTFE).

Setting: Raghudeep Eye Hospital, Ahmedabad, India.

Design: Prospective, interventional case series.

Visual outcomes after toric intraocular lens implantation in pediatric eyes undergoing cataract surgery.

Purpose: To evaluate long-term visual outcomes and complications after toric intraocular lens (IOL) implantation in children with preexisting corneal astigmatism undergoing cataract surgery.

Setting: Iladevi Cataract & IOL Research Center, Ahmedabad, India.

Design: Prospective, interventional case series.

Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy.

Gut microbiome evidenced as the assembling mode of action facilitates the relationship of environmental factors (such as diet and lifestyle) with colorectal cancer. The cytotoxic and anticancer studies of the enzymatically extracted polysaccharides from selected Indian seaweeds (such as S. wightii, E.

Evaluation of collagen derived antiangiogenic factors and matrix metalloproteinases in anterior lens epithelial cells of pediatric eyes with persistent fetal vasculature.

Purpose: To measure levels of collagen-derived antiangiogenic factors (arresten, canstatin, tumstatin, endostatin) and matrix metalloproteinases (MMP-2 and MMP-9) in anterior lens epithelial cells (LECs) and anterior capsules of children with cataract and persistent fetal vasculature (PFV) as cases and cataract without PFV as controls.

Methods: Anterior capsules harboring LECs were collected from pediatric cataract patients with (n = 13) and without PFV (n = 13) during surgery. Samples were immediately subjected to RNA extraction and cDNA preparation.

Decoding the Roadmap for Capacity Building of Pharmacology Academicians in Catering to Drug Information Center Services in a Developing Country.

Very few medical institutions are currently providing drug information center (DIC) services in low-resource countries. To assess whether academician pharmacologists of India are prepared to deliver countrywide services with regard to DICs. A cross-sectional knowledge attitude and practice study was planned in the form of an online survey.

Intraradicular Smear Removal Efficacy of Triphala as a Final Rinse Solution in Curved Canals: A Scanning Electron Microscope Study.

Aim: This study aimed to compare smear layer removal ability of different solutions of Triphala (TA) when used in specific irrigant protocols in curved canals.

Materials And Methods: Seventy-four mandibular first molars with 25-35 degrees of curvature of mesial roots were selected and standardized, and canals were prepared. As the initial rinse solution (8 mL), 5% sodium hypochlorite was used.

Incorporating Optical Coherence Tomography in the Cataract Preoperative Armamentarium: Additional Need or Additional Burden?

Purpose: To determine the usefulness of preoperative optical coherence tomography (OCT) examination to detect asymptomatic macular abnormalities in patients scheduled for cataract surgery.

Methods: Design: Prospective, interventional case series.

Setting: Iladevi Cataract and Visakha Eye Center, Ahmedabad, India.

Five-Year Postoperative Outcomes of Bilateral Aphakia and Pseudophakia in Children up to 2 Years of Age: A Randomized Clinical Trial.

Purpose: Comparative evaluation of complications and visual outcomes following bilateral congenital cataract surgery in children up to 2 years of age with and without primary intraocular lens (IOL) implantation at 5 years follow-up.

Design: Randomized controlled clinical trial.

Methods: Sixty children (120 eyes) up to 2 years of age undergoing bilateral congenital cataract surgery were randomized to Group 1, primary aphakia (n = 30), or Group 2, primary IOL implantation (pseudophakia) (n = 30).

Comparison of ocular wavefront aberrations in subluxated lenses before and after lens extraction with intraocular lens implantation.

Purpose: To compare the change in ocular higher-order wavefront aberrations (HOAs), visual acuity, and modulation transfer function (MTF) after lens extraction with intraocular lens (IOL) implantation in patients with subluxated lenses.

Setting: Iladevi Cataract & IOL Research Centre, Ahmedabad, India.

Design: Prospective case series.