is a human-pathogenic bacterium of the gastrointestinal tract. This study aimed at the contribution of the mucosal immune system in the context of intestinal epithelial barrier dysfunction induced by . As an experimental leaky gut model, we used in vitro co-cultures of colonic epithelial cell monolayers (HT-29/B6-GR/MR) with M1-macrophage-like THP-1 cells on the basal side.
View Article and Find Full Text PDFis a widespread zoonotic pathogen and the leading bacterial cause of foodborne gastroenteritis in humans. Previous infection studies showed disruption of intercellular contacts, induction of epithelial apoptosis, and immune activation, all three contributing to intestinal barrier dysfunction leading to diarrhea. The present study aims to determine the impact of subepithelial immune cells on intestinal barrier dysfunction during infection and the underlying pathological mechanisms.
View Article and Find Full Text PDFThe epithelial sodium channel (ENaC) can increase the colonic absorptive capacity for salt and water. is a common pathogenic epsilonproteobacterium, causing enteritis and diarrhea. It can induce barrier dysfunction in the intestine, but its influence on intestinal transport function is still unknown.
View Article and Find Full Text PDF() is the most common cause of foodborne gastroenteritis worldwide. The bacteria induce diarrhea and inflammation by invading the intestinal epithelium. Curcumin is a natural polyphenol from turmeric rhizome of , a medical plant, and is commonly used in curry powder.
View Article and Find Full Text PDFThe Gram-negative alphaproteobacterium Jannaschia aquimarina GSW-M26 (DSM 28248) is a member of the Roseobacter clade. The size of the draft genome is 4.1 Mb.
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