Design and Synthesis of Quinazolinone-Triazole Hybrids as Potent Anti-Tubercular Agents.

A straightforward and convenient methodology has been developed for the reaction of 2-aminobenzamide and carbonyls affording 2,3-dihydroquinazolin-4(1)-ones using aqueous solution of [CPy][FeClBr]. The developed methodology was applied for the synthesis of 25 quinazolinone-triazole hybrids followed by evaluation of their anti-tubercular (TB) activity. The results revealed that 8 quinazolinone-triazole hybrids displayed promising activity having MIC values of 0.

Species Composition and Diversity Dynamics of Actinomycetes in Arid and Semi-arid Salt Basins of Rajasthan.

Species composition and diversity dynamics of the actinomycetes was studied in five salt basins of arid and semi-arid areas of Rajasthan, India. A novel approach integrating molecular (16S rRNA gene) and diversity indices was applied to reveal species composition and diversity dynamics. Fifty-three actinomycetes isolates were isolated from five arid and semi-arid salt basins.

In-Silico Validation of Therapeutic Peptides Against Fungal Cell Wall: Better Treatment Strategy for Fungal Diseases.

commonly known as Druce are valuable herb that holds antibacterial role, antifungal properties. We identified different peptides from this plant by deploying CADD (Computer-aided-drug-designing) approaches, these peptide sequences are as follows seq1 (RHDEEEEKAKV),seq3(KSNSTVEISQNVQSVDSSKM),seq4(KQVAEMNKPAVGSKTSDANHDLKS),seq5(KTKSAGNDSIQSTKPVPSALTVDKA),seq6(RELEDSNIHHVAASVVLESKSSRT), and seq8(LYSKVELHPFGLHNLGNSCYANAVFSV), these peptides holds therapeutic properties as shows interaction with chitin, a major constituent of fungal cell wall. Molecular docking was conducted by using AutoDock-Vina tool and the results were found to be promising where all binding energies were found in the range of - 9.

Actinomycetes isolates of arid zone of Indian Thar Desert and efficacy of their bioactive compounds against human pathogenic bacteria.

Twenty-six morphotypes of actinomycetes bacteria were isolated from the soils of arid zone of Indian Thar desert, Rajasthan. A significant and positive correlation was found between density of actinomycetes isolates and availability of nitrogen in sandy soil of arid zone suggesting the influence of soil nitrogen on occurrence and propagation of actinomycetes in this region. Molecular identification based on 16S rRNA gene sequencing revealed that the bacterial isolates belong to four actinomycetes genera, viz.

Magnetic proline-based ionic liquid surfactant as a nano-carrier for hydrophobic drug delivery.

Magnetic proline-based surface-active ionic liquid ([ProC][FeClBr]) have been synthesized and investigated for their application in hydrophobic drug delivery. Hydrophobic drugs lead to poor absorptivity, drug aggregation, and high local toxicity. Herein, the vesicular structures formed from [ProC][FeClBr] have been used as drug delivery reactors.

Surface-Active Ionic Liquid Cholinium Dodecylbenzenesulfonate: Self-Assembling Behavior and Interaction with Cellulase.

The conventional sodium dodecylbenzenesulfonate (NaDBS) has been converted into an efficient and nontoxic anionic surface-active ionic liquid, cholinium dodecylbenzenesulfonate (Cho[DBS]). We have investigated its self-assembling behavior, interaction with the enzyme cellulase, and ecotoxicity. The surface-active properties at the air-liquid interface and the aggregation behavior of Cho[DBS] in water have been determined using tensiometry, isothermal titration calorimetry (ITC), conductometry, and dynamic light scattering (DLS).

Synthesis and biological evaluation of novel 1,2,3-triazole derivatives as anti-tubercular agents.

A library of seventeen novel 1,2,3-triazole derivatives were efficiently synthesized in excellent yields by the popular 'click chemistry' approach and evaluated in vitro for their anti-tubercular activity against Mycobacterium tuberculosis H37Ra (ATCC 25177 strain). Among the series, six compounds exhibited significant activity with minimum inhibitory concentration (MIC) values ranging from 3.12 to 0.

Occurrence and characterization of hitherto unknown Streptomyces species in semi-arid soils.

Streptomyces the predominant genus of Actinobacteria and plays an important role in the recycling of soil organic matter and production of important secondary metabolites. The occurrence and diversity assessment of Streptomyces species revealed alkaline and poor nutrient status of soils of semi-arid region of Jodhpur, Rajasthan. The morphological and biochemical characterization of 21 Streptomyces isolates facilitated Genus level identification but were insufficient to designate species.

Illuminating microemulsions: ionic liquid-CdS quantum dots hybrid materials as potential white light harvesting systems.

Microemulsions (MEs) comprising of 2-hydroxyethylammonium formate, (HO-EAF), isooctane and dioctylsulfosuccinate proliniumisopropylester ([ProC3]AOT) have been constructed and used to prepare and stabilize CdS Quantum Dots (QDs) at room temperature. Such hybrid materials exhibited tunable light emission wherein the photoluminescence chromaticity could be precisely adjusted to pure white with a quantum efficiency (QE) of ∼43%, by adjusting the droplet size of MEs.

Synergistic effects of Arbuscular mycorrhizal fungi and plant growth promoting rhizobacteria in bioremediation of iron contaminated soils.

Three Arbuscular mycorrhizal fungi (AMF) from Glomus, Acaulospora and Scutellospora, and four plant growth promoting rhizobacteria (PGPR) isolates related to genera Streptomyces, Azotobacter, Pseudomonas and Paenibacillus were found to be effective in phytoremediation of Fe(3+) contaminated soil where Pennisetum glaucum and Sorghum bicolor were growing as host plants. Co-inoculation of AMF and PGPR showed better results in comparison to either, AMF and PGPR under pot conditions. Both AMF and PGPR were able to produce siderophores.

Spontaneous Formation of Multiarchitecture Vesicles of [C8mim]Br + [Na]DBS in Aqueous Medium: Synergic Interplay of Electrostatic, Hydrophobic, and π-π Stacking Interactions.

A mixture of a cationic surface active ionic liquid, [C8mim]Br and anionic surfactant, [Na]DBS has been shown to form unilamellar vesicles in water over an exceptionally wide mole fraction range of [C8mim]Br (x1 = 0.2 to 0.8).

Sodium bromide induced micelle to vesicle transitions of newly synthesized anionic surface active ionic liquids based on dodecylbenzenesulfonate.

Dodecylbenezenesulfonate-based anionic surface active ionic liquids (DBS-ILs) paired with onium cations, n-butyltrimethylammonium ([N1114]), 1-butyl-3-methylimidazolium ([C4mim]), and N-butylpyridinium ([C4Py]) have been synthesized. DBS-ILs were found to be highly surface active having critical micelle concentration (CMC) lower than that of their conventional analogue sodium dodecylbenezenesulfonate ([Na][DBS]). The CMC values of DBS-ILs were determined from surface tension (ST) and isothermal titration calorimetry (ITC).

Temperature-dependent solubility transition of Na₂SO₄ in water and the effect of NaCl therein: solution structures and salt water dynamics.

Dual, aqueous solubility behavior of Na2SO4 as a function of temperatures is still a natural enigma lying unresolved in the literature. The solubility of Na2SO4 increases up to 32.38 °C and decreases slightly thereafter at higher temperatures.

Self-assembly of new surface active ionic liquids based on Aerosol-OT in aqueous media.

New anionic ionic liquid surfactants have been synthesized by replacing the sodium cation of Aerosol-OT (sodium dioctylsulfosuccinate, [Na]AOT) with various biocompatible moieties, such as 1-butyl-3-methyl imidazolium ([C4mim]), proliniumisopropylester ([ProC3]), cholinium ([Cho]), and guanidinium ([Gua]). The Aerosol-OT derived ionic liquids (AOT-ILs) were found fairly soluble in water and formed vesicles above a critical vesicle concentration (CVC) which depended upon the nature of cation, and followed the order: [ProC3]<[C4mim]<[Gua]<[Cho] View Article and Find Full Text PDF

Morphometric and molecular characterization of fungus Pestalotiopsis using nuclear ribosomal DNA analysis.

Taxonomy of the fungus Pestalotiopsis based on morphological characters has been equivocal. Molecular characterization often Pestalotiopsis species was done based on nuclear ribosomal DNA internal transcribed spacer (ITS) amplifications. Results of the analyses showed that species of genus Pestalotiopsis are monophyletic.