Publications by authors named "Pratyaksha Singh"
Exploring mammalian heme peroxidases: A comprehensive review on the structure and function of myeloperoxidase, lactoperoxidase, eosinophil peroxidase, thyroid peroxidase and peroxidasin.
Ekampreet Singh Ayushi Gupta Pratyaksha Singh Monika Jain Jayaraman Muthukumaran Rashmi Prabha Singh Amit Kumar Singh
Arch Biochem Biophys
November 2024
Article Synopsis
- - The peroxidase family of enzymes, particularly mammalian heme peroxidases, are essential for oxidizing various organic and inorganic substances, and are characterized by a heme group important for their activity.
- - Key members of this family include Lactoperoxidase (LPO), Eosinophil peroxidase (EPO), Myeloperoxidase (MPO), Thyroid peroxidase (TPO), and Peroxidasin (PXDN), each serving distinct biological functions like antibacterial actions and thyroid hormone synthesis.
- - Despite their beneficial roles, dysfunctions in these enzymes are linked to diseases such as myocardial infarction, asthma, and Alzheimer’s, making their study critical for understanding both health and
The opportunistic bacterium , which belongs to ESKAPE group of pathogenic bacteria, is leading cause of infections associated with gram-negative bacteria. causes severe diseases, such as VAP (ventilator-associated pneumonia), meningitis, and UTI (urinary tract infections) among the nosocomial infections contracted in hospitals. The high infection rate and growing resistance to the vast array of antibiotics makes it paramount to look for new therapeutic strategies against this pathogen.
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