Publications by authors named "Pratip Kumar Dutta"
The spiro[pyrrolidine-3, 3´-oxindole] moiety is present as a core in number of alkaloids with substantial biological activities. Here in we report design and synthesis of a library of compounds bearing spiro[pyrrolidine-3, 3´-oxindole] motifs that demonstrated exceptional inhibitory activity against the proliferation of MCF-7 breast cancer cells. The synthesis involved a one pot Pictet Spengler-Oxidative ring contraction of tryptamine to the desired scaffolds and occurred in 1:1 THF and water with catalytic trifluoroacetic acid and stoichiometric N-bromosuccinimide as an oxidant.
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- The study presents a unique reaction process that transforms 2-aminobenzylamines into 2-substituted benzimidazoles using oxone, occurring at room temperature with various types of aldehydes.
- The reaction starts with the condensation of 2-aminobenzylamine and aldehydes, producing a tetrahydroquinazoline intermediate.
- This intermediate then undergoes a modification through oxone treatment, resulting in the successful synthesis of the target compounds with moderate to excellent yields.